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TKNM_ODOMA
ID   TKNM_ODOMA              Reviewed;          14 AA.
AC   P40951;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   11-DEC-2019, entry version 51.
DE   RecName: Full=Ranamargarin;
OS   Odorrana margaretae (Chinese frog) (Rana margaratae).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX   NCBI_TaxID=121156;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-14.
RC   TISSUE=Skin secretion;
RX   PubMed=2803524;
RA   Tang Y.Q., Tian S.H., Wu S.X., Hua J.C., Wu G.F., Zhao E.M., Lu Y.A.,
RA   Zhu Y.Q., Zou G., Tsou K.;
RT   "Isolation and structure of ranamargarin, a new tachykinin from the skin of
RT   Chinese frog Rana margaratae.";
RL   Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 32:570-579(1989).
RN   [2]
RP   SYNTHESIS.
RX   PubMed=2340087;
RA   Lu Y.A., Peng J.L., Zhu Y.Q., Wu S.X., Tang Y.Q., Tian S.H., Zou G.;
RT   "Synthesis and biological activity of a new frog skin peptide,
RT   ranamargarin.";
RL   Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 33:170-177(1990).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Neuropeptide; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Ranamargarin"
FT                   /id="PRO_0000044409"
FT   MOD_RES         14
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:2803524"
SQ   SEQUENCE   14 AA;  1617 MW;  D4593AE408C3673D CRC64;
     DDASDRAKKF YGLM
 
 
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