TKNM_ODOMA
ID TKNM_ODOMA Reviewed; 14 AA.
AC P40951;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 11-DEC-2019, entry version 51.
DE RecName: Full=Ranamargarin;
OS Odorrana margaretae (Chinese frog) (Rana margaratae).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX NCBI_TaxID=121156;
RN [1]
RP PROTEIN SEQUENCE, AND AMIDATION AT MET-14.
RC TISSUE=Skin secretion;
RX PubMed=2803524;
RA Tang Y.Q., Tian S.H., Wu S.X., Hua J.C., Wu G.F., Zhao E.M., Lu Y.A.,
RA Zhu Y.Q., Zou G., Tsou K.;
RT "Isolation and structure of ranamargarin, a new tachykinin from the skin of
RT Chinese frog Rana margaratae.";
RL Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 32:570-579(1989).
RN [2]
RP SYNTHESIS.
RX PubMed=2340087;
RA Lu Y.A., Peng J.L., Zhu Y.Q., Wu S.X., Tang Y.Q., Tian S.H., Zou G.;
RT "Synthesis and biological activity of a new frog skin peptide,
RT ranamargarin.";
RL Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 33:170-177(1990).
CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC behavioral responses, are potent vasodilators and secretagogues, and
CC contract (directly or indirectly) many smooth muscles.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR PROSITE; PS00267; TACHYKININ; 1.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Direct protein sequencing;
KW Neuropeptide; Secreted.
FT PEPTIDE 1..14
FT /note="Ranamargarin"
FT /id="PRO_0000044409"
FT MOD_RES 14
FT /note="Methionine amide"
FT /evidence="ECO:0000269|PubMed:2803524"
SQ SEQUENCE 14 AA; 1617 MW; D4593AE408C3673D CRC64;
DDASDRAKKF YGLM