ID   TKN_ELECI               Reviewed;          11 AA.
AC   P62933; P01293;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   02-JUN-2021, entry version 36.
DE   RecName: Full=Eledoisin;
OS   Eledone cirrhosa (Curled octopus) (Ozaena cirrosa).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Eledone.
OX   NCBI_TaxID=102876;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   MET-11.
RC   TISSUE=Posterior salivary gland;
RX   PubMed=14012712; DOI=10.1016/0003-9861(63)90533-2;
RA   Anastasi A., Erspamer V.;
RT   "The isolation and amino acid sequence of eledoisin, the active
RT   endecapeptide of the posterior salivary glands of Eledone.";
RL   Arch. Biochem. Biophys. 101:56-65(1963).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=12524318; DOI=10.1016/s0006-3495(03)74885-1;
RA   Grace R.C., Chandrashekar I.R., Cowsik S.M.;
RT   "Solution structure of the tachykinin peptide eledoisin.";
RL   Biophys. J. 84:655-664(2003).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   PIR; B01561; EOOCC.
DR   PDB; 1MXQ; NMR; -; A=2-11.
DR   PDBsum; 1MXQ; -.
DR   SMR; P62933; -.
DR   EvolutionaryTrace; P62933; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Direct protein sequencing; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..11
FT                   /note="Eledoisin"
FT                   /id="PRO_0000044393"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:14012712"
FT   MOD_RES         11
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:14012712"
FT   TURN            3..5
FT                   /evidence="ECO:0007829|PDB:1MXQ"
FT   HELIX           6..10
FT                   /evidence="ECO:0007829|PDB:1MXQ"
SQ   SEQUENCE   11 AA;  1206 MW;  570D7C2559CDDAA3 CRC64;
     QPSKDAFIGL M