ID   TKN_KASSE               Reviewed;          12 AA.
AC   P08611;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   02-JUN-2021, entry version 75.
DE   RecName: Full=Kassinin;
OS   Kassina senegalensis (Senegal running frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Microhyloidea; Hyperoliidae; Kassina.
OX   NCBI_TaxID=8415;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-12.
RC   TISSUE=Skin secretion;
RX   PubMed=891753; DOI=10.1007/bf01951242;
RA   Anastasi A., Montecucchi P.C., Erspamer V., Visser J.;
RT   "Amino acid composition and sequence of kassinin, a tachykinin
RT   dodecapeptide from the skin of the African frog Kassina senegalensis.";
RL   Experientia 33:857-858(1977).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   PIR; S07206; S07206.
DR   PDB; 1MYU; NMR; -; A=1-12.
DR   PDBsum; 1MYU; -.
DR   BMRB; P08611; -.
DR   SMR; P08611; -.
DR   EvolutionaryTrace; P08611; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Amphibian defense peptide;
KW   Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Kassinin"
FT                   /id="PRO_0000044397"
FT   MOD_RES         12
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:891753"
FT   HELIX           4..11
FT                   /evidence="ECO:0007829|PDB:1MYU"
SQ   SEQUENCE   12 AA;  1336 MW;  91757AB89DD6DAB5 CRC64;
     DVPKSDQFVG LM