ID   TKN_PHYBI               Reviewed;          10 AA.
AC   P08610;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   11-DEC-2019, entry version 60.
DE   RecName: Full=Phyllomedusin;
OS   Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8393;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   MET-10.
RC   TISSUE=Skin secretion;
RX   PubMed=5452018; DOI=10.1007/bf02114227;
RA   Anastasi A., Erspamer G.F.;
RT   "Occurrence of phyllomedusin, a physalaemin-like decapeptide, in the skin
RT   of Phyllomedusa bicolor.";
RL   Experientia 26:866-867(1970).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons, evoke
CC       behavioral responses, are potent vasodilators and secretagogues, and
CC       contract (directly or indirectly) many smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   PIR; S07202; S07202.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Phyllomedusin"
FT                   /id="PRO_0000044398"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:5452018"
FT   MOD_RES         10
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:5452018"
SQ   SEQUENCE   10 AA;  1189 MW;  3A257D7059D40457 CRC64;
     QNPNRFIGLM