TKR1_CAEEL
ID TKR1_CAEEL Reviewed; 406 AA.
AC Q03566;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Probable G-protein coupled receptor tkr-1;
DE AltName: Full=Tachykinin receptor family protein 1;
GN Name=tkr-1; ORFNames=C38C10.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Not known. Putative receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; Z19153; CAA79546.2; -; Genomic_DNA.
DR PIR; S28285; S28285.
DR RefSeq; NP_499064.2; NM_066663.4.
DR AlphaFoldDB; Q03566; -.
DR SMR; Q03566; -.
DR STRING; 6239.C38C10.1; -.
DR PaxDb; Q03566; -.
DR EnsemblMetazoa; C38C10.1.1; C38C10.1.1; WBGene00006576.
DR GeneID; 192055; -.
DR KEGG; cel:CELE_C38C10.1; -.
DR CTD; 192055; -.
DR WormBase; C38C10.1; CE44282; WBGene00006576; tkr-1.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000153745; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; Q03566; -.
DR OMA; MCRLARF; -.
DR OrthoDB; 715197at2759; -.
DR PhylomeDB; Q03566; -.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q03566; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006576; Expressed in larva and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004995; F:tachykinin receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..406
FT /note="Probable G-protein coupled receptor tkr-1"
FT /id="PRO_0000070225"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 406 AA; 46350 MW; 86FA2ACD421E3D69 CRC64;
MNQEFLIQLG ERACKNAENL TLPAELEGIF FCAPSSRESL ATQVFVAIAF VLLMATAIIG
NSVVMWIIYQ HKVMHYGFNY FLFNMAFADL LIALFNVGTS WTYNLYYDWW YGDLCTLTSF
FGIAPTTVSV CSMMALSWDR CQAVVNPLQK RPLSRKRSVI AILIIWVVST VTALPFAIAA
SVNSLYTYDV VTSTVSKAHV CSAPVNTFFE KVLFGIQYAL PIIILGSTFT RIAVAFRATN
EATDSSLKNN HTRAKSKAVK MLFLMVVAFV VCWLPYHIYH AFALEEFFDA ARGKYAYLLI
YWIAMSSCAY NPIIYCFANE RFRIGFRYVF RWIPVIDCKK EQYEYSQLFP DKMRSMAISL
QKGRVNSSCL DKKVKENSSQ DLVCVMHSEK NTKKYSKVHL LSCHER
