TKSIA_AEDAE
ID TKSIA_AEDAE Reviewed; 85 AA.
AC P42634; P42635; Q17PU8; Q9TW63; Q9UAR7; Q9UAR8;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Prosialokinin;
DE Contains:
DE RecName: Full=Sialokinin;
DE AltName: Full=Sialokinin I;
DE Short=Sia I;
DE AltName: Full=Sialokinin II;
DE Short=Sia II;
DE AltName: Full=Sialokinin-1;
DE AltName: Full=Sialokinin-2;
DE Flags: Precursor;
GN ORFNames=AAEL000229;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND VARIANT ASP-75.
RC STRAIN=Rockefeller; TISSUE=Salivary gland;
RX PubMed=10620041; DOI=10.1046/j.1365-2583.1999.00141.x;
RA Beerntsen B.T., Champagne D.E., Coleman J.L., Campos Y.A., James A.A.;
RT "Characterization of the sialokinin I gene encoding the salivary
RT vasodilator of the yellow fever mosquito, Aedes aegypti.";
RL Insect Mol. Biol. 8:459-467(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3]
RP PROTEIN SEQUENCE OF 75-84, AMIDATION AT MET-84, AND FUNCTION.
RC STRAIN=Rockefeller; TISSUE=Salivary gland;
RX PubMed=8278354; DOI=10.1073/pnas.91.1.138;
RA Champagne D.E., Ribeiro J.M.C.;
RT "Sialokinin I and II: vasodilatory tachykinins from the yellow fever
RT mosquito Aedes aegypti.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:138-142(1994).
CC -!- FUNCTION: Vasodilatory peptide. May activate macrophages at the site of
CC feeding. {ECO:0000269|PubMed:10620041, ECO:0000269|PubMed:8278354}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10620041}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in the medial lobe of female
CC salivary glands. {ECO:0000269|PubMed:10620041}.
CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR EMBL; AF108099; AAD17916.1; -; Genomic_DNA.
DR EMBL; AF108100; AAD16884.1; -; mRNA.
DR EMBL; AF108101; AAD16885.1; -; mRNA.
DR EMBL; AF108102; AAD16886.1; -; mRNA.
DR EMBL; CH477189; EAT48743.1; -; Genomic_DNA.
DR PIR; A49581; A49581.
DR PIR; B49581; B49581.
DR RefSeq; XP_001660125.1; XM_001660075.1.
DR AlphaFoldDB; P42634; -.
DR STRING; 7159.AAEL000229-PA; -.
DR GeneID; 5572020; -.
DR KEGG; aag:5572020; -.
DR VEuPathDB; VectorBase:AAEL000229; -.
DR HOGENOM; CLU_2514453_0_0_1; -.
DR Proteomes; UP000008820; Chromosome 1.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR PROSITE; PS00267; TACHYKININ; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..74
FT /evidence="ECO:0000255"
FT /id="PRO_0000344495"
FT PEPTIDE 75..84
FT /note="Sialokinin"
FT /id="PRO_0000044430"
FT REGION 26..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Methionine amide"
FT /evidence="ECO:0000269|PubMed:8278354"
FT VARIANT 75
FT /note="N -> D (in allele Red)"
FT /evidence="ECO:0000269|PubMed:10620041"
FT CONFLICT 2
FT /note="N -> K (in Ref. 1; AAD17916)"
FT /evidence="ECO:0000305"
FT CONFLICT 15
FT /note="L -> F (in Ref. 1; AAD17916)"
FT /evidence="ECO:0000305"
FT CONFLICT 24
FT /note="L -> F (in Ref. 1; AAD17916)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="R -> T (in Ref. 1; AAD16886/AAD16885)"
FT /evidence="ECO:0000305"
FT CONFLICT 50..51
FT /note="DP -> NT (in Ref. 1; AAD16886/AAD16885)"
FT /evidence="ECO:0000305"
FT CONFLICT 54
FT /note="K -> E (in Ref. 1; AAD16886/AAD16885)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 85 AA; 9377 MW; 64152347F70A8A81 CRC64;
MNMFITVQIV IVLVLAVLSE AASLPTATER KDAMDEGPNQ SDEPEGSVAD PSTKDDDYSD
SLKQDEKYYK VRLLNTGDKF YGLMG
