ID   TKTI1_BOVIN             Reviewed;         208 AA.
AC   Q2M2T2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Tektin bundle interacting protein 1 {ECO:0000305};
DE   AltName: Full=Uncharacterized protein C19orf71 homolog;
GN   Name=TEKTIP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. Located at the center of the tektin bundle where
CC       may function to recruit tektins or stabilize the bundle.
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
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DR   EMBL; BC111650; AAI11651.1; -; mRNA.
DR   RefSeq; NP_001070550.1; NM_001077082.1.
DR   PDB; 7RRO; EM; 3.40 A; E0/E1/E2/E3=1-208.
DR   PDBsum; 7RRO; -.
DR   AlphaFoldDB; Q2M2T2; -.
DR   PaxDb; Q2M2T2; -.
DR   GeneID; 768023; -.
DR   KEGG; bta:768023; -.
DR   CTD; 100128569; -.
DR   eggNOG; ENOG502S0K8; Eukaryota.
DR   OrthoDB; 938354at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   InterPro; IPR029203; DUF4531.
DR   PANTHER; PTHR31254; PTHR31254; 1.
DR   Pfam; PF15041; DUF4531; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..208
FT                   /note="Tektin bundle interacting protein 1"
FT                   /id="PRO_0000332194"
SQ   SEQUENCE   208 AA;  24500 MW;  1D33CF5802BC9DD3 CRC64;
     MQTLRRQAAW PCVPRGTLEV DFPPPLYSDD YLSQEGPRWT PAIKQATRWK YTPMGRDAAG
     QLWYTGLTNS DSREAWYTLP RAPDSPYREA YARWHGCYGH RERSLPSAYT QRLRETAWYD
     PIIPAQYTDP STRWGSVLWK DRPIRGKEFA INRHRFGVEA LWRASDYVRY LSAPQRPRYT
     AQNYRQWGLE PYCPATNQRP PPVYTPSH