TKTI1_HUMAN
ID TKTI1_HUMAN Reviewed; 209 AA.
AC A6NCJ1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Tektin bundle interacting protein 1 {ECO:0000305};
GN Name=TEKTIP1 {ECO:0000312|HGNC:HGNC:34496}; Synonyms=C19orf71;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. Located at the center of the tektin bundle where
CC may function to recruit tektins or stabilize the bundle.
CC {ECO:0000250|UniProtKB:Q2M2T2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q2M2T2}.
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DR EMBL; AC005786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45918.1; -.
DR RefSeq; NP_001129052.1; NM_001135580.1.
DR AlphaFoldDB; A6NCJ1; -.
DR BioGRID; 933564; 1.
DR STRING; 9606.ENSP00000327950; -.
DR iPTMnet; A6NCJ1; -.
DR PhosphoSitePlus; A6NCJ1; -.
DR BioMuta; C19orf71; -.
DR MassIVE; A6NCJ1; -.
DR PaxDb; A6NCJ1; -.
DR PeptideAtlas; A6NCJ1; -.
DR PRIDE; A6NCJ1; -.
DR ProteomicsDB; 839; -.
DR Antibodypedia; 63437; 10 antibodies from 6 providers.
DR DNASU; 100128569; -.
DR Ensembl; ENST00000329493.6; ENSP00000327950.4; ENSG00000183397.6.
DR GeneID; 100128569; -.
DR KEGG; hsa:100128569; -.
DR MANE-Select; ENST00000329493.6; ENSP00000327950.4; NM_001135580.2; NP_001129052.1.
DR UCSC; uc010xhm.3; human.
DR CTD; 100128569; -.
DR GeneCards; C19orf71; -.
DR HGNC; HGNC:34496; TEKTIP1.
DR HPA; ENSG00000183397; Tissue enriched (testis).
DR neXtProt; NX_A6NCJ1; -.
DR OpenTargets; ENSG00000183397; -.
DR VEuPathDB; HostDB:ENSG00000183397; -.
DR eggNOG; ENOG502S0K8; Eukaryota.
DR GeneTree; ENSGT00390000004282; -.
DR HOGENOM; CLU_108079_0_0_1; -.
DR InParanoid; A6NCJ1; -.
DR OMA; YGVEPLW; -.
DR PhylomeDB; A6NCJ1; -.
DR TreeFam; TF336002; -.
DR PathwayCommons; A6NCJ1; -.
DR SignaLink; A6NCJ1; -.
DR BioGRID-ORCS; 100128569; 12 hits in 1045 CRISPR screens.
DR GenomeRNAi; 100128569; -.
DR Pharos; A6NCJ1; Tdark.
DR PRO; PR:A6NCJ1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NCJ1; protein.
DR Bgee; ENSG00000183397; Expressed in right testis and 93 other tissues.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR029203; DUF4531.
DR PANTHER; PTHR31254; PTHR31254; 1.
DR Pfam; PF15041; DUF4531; 1.
PE 3: Inferred from homology;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..209
FT /note="Tektin bundle interacting protein 1"
FT /id="PRO_0000332195"
FT VARIANT 83
FT /note="P -> L (in dbSNP:rs12608919)"
FT /id="VAR_061253"
FT VARIANT 137
FT /note="A -> V (in dbSNP:rs6510758)"
FT /id="VAR_061254"
SQ SEQUENCE 209 AA; 24176 MW; 2D40E238DBA50289 CRC64;
MQTLRQEAAR PCIPSGTLEA SFPAPLYSDD YLSLEGSRWP PAIRQATRWK YTPMGRDAAG
QLWYTGLTNS DAWEAWYNLP RAPASPFREA YNRWHSCYQH RECSMPSAYT QHLRETAWHD
PIVPAQYQAP STRWGSALWK DRPIRGKEYV LNRNRYGVEP LWRASDYVPS LSAPQRPPGT
TQNYREWVLE PYCPSTCQRS PPSLTPTPR
