TKTI1_MOUSE
ID TKTI1_MOUSE Reviewed; 206 AA.
AC A6H6Q4; B9EI87; Q9D5N6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Tektin bundle interacting protein 1 {ECO:0000305};
GN Name=Tektip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. Located at the center of the tektin bundle where
CC may function to recruit tektins or stabilize the bundle.
CC {ECO:0000250|UniProtKB:Q2M2T2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q2M2T2}.
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DR EMBL; AK015088; BAB29709.1; -; mRNA.
DR EMBL; BC139256; AAI39257.1; -; mRNA.
DR EMBL; BC145960; AAI45961.1; -; mRNA.
DR CCDS; CCDS24056.1; -.
DR RefSeq; NP_001014836.2; NM_001014836.3.
DR AlphaFoldDB; A6H6Q4; -.
DR BioGRID; 240634; 1.
DR STRING; 10090.ENSMUSP00000020456; -.
DR PhosphoSitePlus; A6H6Q4; -.
DR PaxDb; A6H6Q4; -.
DR PRIDE; A6H6Q4; -.
DR Antibodypedia; 63437; 10 antibodies from 6 providers.
DR Ensembl; ENSMUST00000020456; ENSMUSP00000020456; ENSMUSG00000020234.
DR GeneID; 432479; -.
DR KEGG; mmu:432479; -.
DR UCSC; uc007ghq.2; mouse.
DR MGI; MGI:1921072; 4930404N11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000020234; -.
DR eggNOG; ENOG502S0K8; Eukaryota.
DR GeneTree; ENSGT00390000004282; -.
DR HOGENOM; CLU_108079_0_0_1; -.
DR InParanoid; A6H6Q4; -.
DR OMA; YGVEPLW; -.
DR OrthoDB; 1400323at2759; -.
DR TreeFam; TF336002; -.
DR BioGRID-ORCS; 432479; 1 hit in 39 CRISPR screens.
DR PRO; PR:A6H6Q4; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; A6H6Q4; protein.
DR Bgee; ENSMUSG00000020234; Expressed in spermatid and 41 other tissues.
DR ExpressionAtlas; A6H6Q4; baseline and differential.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR029203; DUF4531.
DR PANTHER; PTHR31254; PTHR31254; 1.
DR Pfam; PF15041; DUF4531; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..206
FT /note="Tektin bundle interacting protein 1"
FT /id="PRO_0000332197"
FT CONFLICT 161
FT /note="P -> S (in Ref. 1; BAB29709)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 206 AA; 23954 MW; A9CCEA7B8CB430B1 CRC64;
MENVRREATR PSVPSGTLEL YFPDHLYRND YVSLEGPRWA PAIKQAVRWK FTPMGRDAAG
QVWFTGLTNS EPGDAWYKLP RALDTPYREA HTRWHGCFQS RQRGLPPAYT QHLREMAFWD
PAITAQYLNS GPRWGCMQWR DRQIRGKEFV VTRNQFGAKL PWRSDYVPLL SLPQRPRFTA
QDFRQRGLQR PCPAIGQPPP AFTPAL
