ID   TLC3A_MOUSE             Reviewed;         257 AA.
AC   Q5ND56;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=TLC domain-containing protein 3A {ECO:0000305};
DE   AltName: Full=Protein FAM57A;
GN   Name=Tlcd3a; Synonyms=Fam57a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBUNIT: Interacts with GGT7 isoform 3 and SLC3A2.
CC       {ECO:0000250|UniProtKB:Q8TBR7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TBR7};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TBR7}.
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DR   EMBL; AL591129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS36230.1; -.
DR   RefSeq; NP_082049.1; NM_027773.3.
DR   AlphaFoldDB; Q5ND56; -.
DR   STRING; 10090.ENSMUSP00000091553; -.
DR   PhosphoSitePlus; Q5ND56; -.
DR   PaxDb; Q5ND56; -.
DR   PRIDE; Q5ND56; -.
DR   ProteomicsDB; 266825; -.
DR   Antibodypedia; 77439; 4 antibodies from 3 providers.
DR   Ensembl; ENSMUST00000094014; ENSMUSP00000091553; ENSMUSG00000069808.
DR   GeneID; 116972; -.
DR   KEGG; mmu:116972; -.
DR   UCSC; uc007kfg.2; mouse.
DR   CTD; 79850; -.
DR   MGI; MGI:2151840; Tlcd3a.
DR   VEuPathDB; HostDB:ENSMUSG00000069808; -.
DR   eggNOG; KOG4561; Eukaryota.
DR   GeneTree; ENSGT01010000222313; -.
DR   InParanoid; Q5ND56; -.
DR   OMA; IYDRHWL; -.
DR   OrthoDB; 1354968at2759; -.
DR   PhylomeDB; Q5ND56; -.
DR   TreeFam; TF324847; -.
DR   BioGRID-ORCS; 116972; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Fam57a; mouse.
DR   PRO; PR:Q5ND56; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q5ND56; protein.
DR   Bgee; ENSMUSG00000069808; Expressed in esophagus and 172 other tissues.
DR   ExpressionAtlas; Q5ND56; baseline and differential.
DR   Genevisible; Q5ND56; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="TLC domain-containing protein 3A"
FT                   /id="PRO_0000185541"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..249
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   257 AA;  29467 MW;  29823E883BD962AA CRC64;
     MLLTLASGAL FFPGLFALSI WALHRLRPGW TEDDCLTVGT RLVSSVQAVL ATWAGLTVII
     SCKNVVSDRH WLATEYVWFL IPYMIYDFYA MYCCERCRTK SQKLTRTTII RNFLIENRLM
     VTHHTVILLF LVPISQKLRG DLGDFFVGCI FTAELSTPFV SLARIMIQLK QQHTLLYKVN
     GILTVTTFLF CRILLFPFMY WSYGQQKGLS LLQVPFNIPL HCNMANAVLI SPQLYWFSLL
     CKKAARLFDT AKAKKDG