ID   TLC4A_XENLA             Reviewed;         258 AA.
AC   Q6GLX2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=TLC domain-containing protein 4-A {ECO:0000305};
DE   AltName: Full=Transmembrane protein 56-A;
GN   Name=tlcd4-a; Synonyms=tmem56-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC074322; AAH74322.1; -; mRNA.
DR   RefSeq; NP_001086204.1; NM_001092735.1.
DR   RefSeq; XP_018097512.1; XM_018242023.1.
DR   RefSeq; XP_018097513.1; XM_018242024.1.
DR   AlphaFoldDB; Q6GLX2; -.
DR   DNASU; 444633; -.
DR   GeneID; 444633; -.
DR   KEGG; xla:444633; -.
DR   CTD; 444633; -.
DR   Xenbase; XB-GENE-6254610; tmem56.2.L.
DR   OrthoDB; 1354968at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 444633; Expressed in liver and 13 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..258
FT                   /note="TLC domain-containing protein 4-A"
FT                   /id="PRO_0000286704"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          43..245
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   258 AA;  29555 MW;  51916EBDA7EF5550 CRC64;
     MDDVLISYCV VTGSFLGFQL LFSAISPRLF TKYSSTYRQL SFGKQCEWDS RFVSTNHALI
     VGSACLYILA YDDAVNADPI WGDPFWVKMN VAITCGYLVQ DLLLLARFWK VMRDPYMVCH
     HLAVFYSYGY VLNRGVLPYF ANFRLISELS TPFVNQRWFF DVIGKPRSSW PVLLNGLAMA
     LVFFIVRIAV IPSYYSQVFA TFGTEGYIRL GIGPQVAWIV SCVVLDILNV FWMYKIARGF
     YKVVKAKPDG KPRRNHAD