ID   TLC4B_DANRE             Reviewed;         264 AA.
AC   Q5XIY2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=TLC domain-containing protein 4-B {ECO:0000305};
DE   AltName: Full=Transmembrane protein 56-B;
GN   Name=tlcd4b; Synonyms=tmem56, tmem56b; ORFNames=zgc:92864;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}.
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DR   EMBL; BC083537; AAH83537.1; -; mRNA.
DR   RefSeq; NP_001005924.1; NM_001005924.1.
DR   RefSeq; XP_005168534.1; XM_005168477.3.
DR   AlphaFoldDB; Q5XIY2; -.
DR   STRING; 7955.ENSDARP00000112952; -.
DR   PaxDb; Q5XIY2; -.
DR   Ensembl; ENSDART00000165452; ENSDARP00000130550; ENSDARG00000098224.
DR   Ensembl; ENSDART00000171726; ENSDARP00000133377; ENSDARG00000098224.
DR   GeneID; 449652; -.
DR   KEGG; dre:449652; -.
DR   CTD; 449652; -.
DR   ZFIN; ZDB-GENE-041010-90; tlcd4b.
DR   eggNOG; KOG4561; Eukaryota.
DR   GeneTree; ENSGT01010000222313; -.
DR   HOGENOM; CLU_034597_2_0_1; -.
DR   InParanoid; Q5XIY2; -.
DR   OMA; HANNHTD; -.
DR   OrthoDB; 1354968at2759; -.
DR   PhylomeDB; Q5XIY2; -.
DR   TreeFam; TF324847; -.
DR   PRO; PR:Q5XIY2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   ExpressionAtlas; Q5XIY2; baseline.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..264
FT                   /note="TLC domain-containing protein 4-B"
FT                   /id="PRO_0000286703"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          41..243
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   264 AA;  29927 MW;  52EDD3FB9279DF55 CRC64;
     MDMREVYVVA GSFVGFQLFF SCVSPVLSSN FTQGYGKLPP NKLNDWNSRL VSTVHALIVG
     LFCLYILWYD DAVNEDPVWG DPNLVKLNVA ITCGYLFYDL LLLACNWSTM GDVFFVCHHL
     AALYAYGYVL TRGVLPYFAN FRLISELSTP FVNQRWFFEA LAYPRTHQLV VANGIAMAVV
     FFLVRIAVMP PYWAKVFGII YSPTFEKLGL AIQVAWIISC VCLDILNIIW MYKIARGCYK
     VITGKLKGRK ADSKKTTCVN NHTD