ID   TLC4B_XENLA             Reviewed;         262 AA.
AC   Q6PGS5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=TLC domain-containing protein 4-B {ECO:0000305};
DE   AltName: Full=Transmembrane protein 56-B;
GN   Name=tlcd4-b; Synonyms=tmem56-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}.
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DR   EMBL; BC056848; AAH56848.1; -; mRNA.
DR   RefSeq; NP_001079916.1; NM_001086447.1.
DR   AlphaFoldDB; Q6PGS5; -.
DR   DNASU; 379606; -.
DR   GeneID; 379606; -.
DR   KEGG; xla:379606; -.
DR   CTD; 379606; -.
DR   Xenbase; XB-GENE-5813226; tlcd4.S.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 379606; Expressed in egg cell and 17 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..262
FT                   /note="TLC domain-containing protein 4-B"
FT                   /id="PRO_0000286705"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          44..246
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   262 AA;  29853 MW;  94B6C6D0A0CD2661 CRC64;
     MANFSPLTVF ISVTSLAVFQ FLFHVGSSWL STRLTGGFHK LSARQKIEWN SRTVSSFHAL
     VVGCFCLYIL VYDDAVNADP VWGDPFMVKL NVAVTSGYLI SDLLLIIYYW KEIGDKYFVT
     HHLAALYACY YVLGEGMLPY FGNFRLIAEF STPFVNQRWF FEVLGYSKYS LPNMVNGVLM
     TISFFIVRIA VIPIYYGRVF STFGTEAFHR LGLGAQCAWI ISSVSLDIMN VMWMIKIAKG
     CYKVLYHRDG KLTKTQNNGK LE