ID   TLC4C_DICDI             Reviewed;         272 AA.
AC   Q55BP8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=TLC domain-containing protein 4 C {ECO:0000305};
DE   AltName: Full=Transmembrane protein 56 homolog C;
GN   Name=tlcd4c; Synonyms=tmem56c; ORFNames=DDB_G0270414;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72557.1; -; Genomic_DNA.
DR   RefSeq; XP_646783.1; XM_641691.1.
DR   AlphaFoldDB; Q55BP8; -.
DR   STRING; 44689.DDB0238275; -.
DR   PaxDb; Q55BP8; -.
DR   EnsemblProtists; EAL72557; EAL72557; DDB_G0270414.
DR   GeneID; 8617756; -.
DR   KEGG; ddi:DDB_G0270414; -.
DR   dictyBase; DDB_G0270414; tmem56C.
DR   eggNOG; KOG4561; Eukaryota.
DR   HOGENOM; CLU_034597_0_0_1; -.
DR   InParanoid; Q55BP8; -.
DR   OMA; FITECGI; -.
DR   PhylomeDB; Q55BP8; -.
DR   PRO; PR:Q55BP8; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..272
FT                   /note="TLC domain-containing protein 4 C"
FT                   /id="PRO_0000330733"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          61..261
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   272 AA;  31654 MW;  D3F38DB18634A050 CRC64;
     MSSINGIDNI KFDYEFSNSL YYRNSIFFSI IFFIIYKKSS YITENFFGEL VKKAYTTLTE
     KKKLEWDQRV VSMIHAFLVL PFCIISAVES FKYGDIFYFQ NDSLLMVLSI SSGYFIWDLI
     ICYKDPKLVG TPMIIHAIMG LSSNIYVALP HGRPCFVPIV AILLITEIST IPLNMKGFIQ
     VVNSKSKYYN WSLGAFVITF LVSRCIIGLP FDIYLVYGCI QRWDVFPMDK SLVFITECGI
     QFFLNSYWSF LLIKKLYQTY LNPIPNHKKN ED