ID   TLCA_RICBR              Reviewed;         498 AA.
AC   Q1RGS8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=ADP,ATP carrier protein 1;
DE   AltName: Full=ADP/ATP translocase 1;
GN   Name=tlcA; Synonyms=tlc1; OrderedLocusNames=RBE_1355;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
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DR   EMBL; CP000087; ABE05436.1; -; Genomic_DNA.
DR   RefSeq; WP_011478005.1; NC_007940.1.
DR   AlphaFoldDB; Q1RGS8; -.
DR   STRING; 336407.RBE_1355; -.
DR   EnsemblBacteria; ABE05436; ABE05436; RBE_1355.
DR   KEGG; rbe:RBE_1355; -.
DR   eggNOG; COG3202; Bacteria.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OMA; RKVIWPI; -.
DR   OrthoDB; 427341at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR31187; PTHR31187; 1.
DR   Pfam; PF03219; TLC; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00769; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Disulfide bond; Membrane; Nucleotide-binding;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="ADP,ATP carrier protein 1"
FT                   /id="PRO_0000286481"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        55..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        89..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        114..147
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        169..184
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        206..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        240..279
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        301..320
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        342..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        370..379
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        401..438
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        460..465
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        487..498
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   BINDING         436..442
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..85
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   498 AA;  56416 MW;  62D6A38FB3207AD8 CRC64;
     MSTTKSDNYI SELRKVIWPI ERYENKKFLP MAFMMFCILL NYSTLRSIKD GFVVTDIGAE
     AISFLKTYIV LPSAVIAMIV YVKLCDILKQ ENVFYVITSF FLAYFALFAF VLYPNPDLVH
     PNPEAIESLS LAYPNFKWFI RIVGKWSFAS FYTMAELWGT LMLSLLFWQF ANQITKTDEA
     KRFYSMFGLL ANLALPVTSL IIGYFLHEKT QIVAEHLKFT PLFVIMIISS LAVILTYRWM
     NKNVLTDPKL YDPALVKGKK AKAKMSLIES FKMIFTSKYV GYIALLLIAY GISVNLVEGV
     WKSKLKELHP TKEAYTMYMG QFQAYQGWVA IAFMIIGSNI LRKVSWLTAA MITPLMMLIT
     GIAFFAFIFF DSVIAMYLTG ILASGPLALA VMIGTIQNVL SKGVKYSLFD ATKNMAYIPL
     DKDLRVKGQA AVEVIGGRFG KSGGAIIQST FFIIFPALGF VEATPYFASI FFVIVILWIY
     AVKGLNKEYQ VLVNNTEK