ID   TLCA_RICCN              Reviewed;         498 AA.
AC   Q92JI6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=ADP,ATP carrier protein 1;
DE   AltName: Full=ADP/ATP translocase 1;
GN   Name=tlcA; Synonyms=tlc1; OrderedLocusNames=RC0081;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
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DR   EMBL; AE006914; AAL02619.1; -; Genomic_DNA.
DR   PIR; A97710; A97710.
DR   RefSeq; WP_010976765.1; NC_003103.1.
DR   AlphaFoldDB; Q92JI6; -.
DR   EnsemblBacteria; AAL02619; AAL02619; RC0081.
DR   KEGG; rco:RC0081; -.
DR   PATRIC; fig|272944.4.peg.98; -.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OMA; RKVIWPI; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR31187; PTHR31187; 1.
DR   Pfam; PF03219; TLC; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00769; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Disulfide bond; Membrane; Nucleotide-binding;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="ADP,ATP carrier protein 1"
FT                   /id="PRO_0000286466"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        55..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        89..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        114..147
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        169..184
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        206..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        240..279
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        301..320
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        342..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        370..379
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        401..438
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        460..465
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        487..498
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   BINDING         436..442
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..85
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   498 AA;  56662 MW;  97B5EB9C5BCC56EB CRC64;
     MNNPKNDNYL SELSKVIWPI ERYENKKFLP MAFMMFCILL NYSTLRSIKD GFVVTDIGAE
     AISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENVFYVITSF FLGYFALFAF VLYPYPDLVH
     PDPETIESWS VAYPNVKWFI RIVGKWSFAS FYTMAELWGT MMLSLLFWQF ANQITKTDEA
     KRFYSMFGLL ANLALPVTSV IIGYCLHEKT QIVAEHLKFV PLFVIMITSS FLVILTYRWM
     NKNVLTDPRL YDPALVKEKK AKAKMSLIDS FKMIFTSKYV GYIALLLIAY GVSVNLVEGV
     WKSKVKELYP TKEAYTIYMG KFQFYQGWVA IAFMLIGSNI LRKVSWLTAA MITPLMMLIT
     GAAFFAFIFF DSVIAMHLTG ILASGPLALA VMIGMIQNVL SKGVKYSLFD ATKNMAYIPL
     DKDLRVKGQA AVEVIGGRFG KSGGAIIQST FFILFPAFGF VEATPYFASI FFVIVILWIY
     AVKGLNKEYK VLVNKTEK