ID   TLCB_RICPR              Reviewed;         507 AA.
AC   Q9ZDF2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=ADP,ATP carrier protein 2;
DE   AltName: Full=ADP/ATP translocase 2;
GN   Name=tlcB; Synonyms=tlc2; OrderedLocusNames=RP377;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235271; CAA14836.1; -; Genomic_DNA.
DR   PIR; B71695; B71695.
DR   RefSeq; NP_220760.1; NC_000963.1.
DR   RefSeq; WP_004597535.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZDF2; -.
DR   STRING; 272947.RP377; -.
DR   EnsemblBacteria; CAA14836; CAA14836; CAA14836.
DR   KEGG; rpr:RP377; -.
DR   PATRIC; fig|272947.5.peg.389; -.
DR   eggNOG; COG3202; Bacteria.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OMA; HIVWPIR; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   PANTHER; PTHR31187; PTHR31187; 1.
DR   Pfam; PF03219; TLC; 1.
DR   TIGRFAMs; TIGR00769; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..507
FT                   /note="ADP,ATP carrier protein 2"
FT                   /id="PRO_0000102581"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   507 AA;  58457 MW;  00DB2DFCC51D9D59 CRC64;
     MNIVDSNCTI WHKARNSKFR HIVWPIRSYE LTKFIPMTLL MFFILLNQNL VRSIKDSFVV
     TLISSEVLSF IKLWGEMPMG VLFVILYSKL CNIMTTEQVF RIITSTFLFF FAIFGFILFP
     YKEFFHPNPE LINQYIIVLP HLKWFLIIWG QWSLVLFYIM GELWPVIVFT LLYWQLANKI
     TKVEEAPRFY SFFTLFGQTN LLFSGTVIIY FAKSEHFLLP LFAHLNDTNE ILLKSFITVI
     LISGLICLAL HKLIDKSVVE ADKNIKFKNQ RTDILKLSLL ESAKIILTSR YLGFICLLVM
     SYSMSINLIE GLWMSKVKQL YPATKDFISY HGEVLFWTGV LTLVSAFLGS SLIRIYGWFW
     GAIITPIMMF VAGVMFFSFT IFEQHLGNIV NTLGYSSPLV IIVFIGGLWH VFAKSVKYSL
     FDATKEMVYI PLDNEIKTKG KAAVDVMGAK IGKSIGAIIQ FISFSIFPNA VHNDIAGLLM
     VTFIIVCILW LYGVKVLSQN YNKMIKR