ID   TLCB_RICTY              Reviewed;         507 AA.
AC   Q68WZ7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=ADP,ATP carrier protein 2;
DE   AltName: Full=ADP/ATP translocase 2;
GN   Name=tlcB; Synonyms=tlc2; OrderedLocusNames=RT0366;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
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DR   EMBL; AE017197; AAU03845.1; -; Genomic_DNA.
DR   RefSeq; WP_011190829.1; NC_006142.1.
DR   AlphaFoldDB; Q68WZ7; -.
DR   STRING; 257363.RT0366; -.
DR   EnsemblBacteria; AAU03845; AAU03845; RT0366.
DR   KEGG; rty:RT0366; -.
DR   eggNOG; COG3202; Bacteria.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OMA; HIVWPIR; -.
DR   OrthoDB; 427341at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   PANTHER; PTHR31187; PTHR31187; 1.
DR   Pfam; PF03219; TLC; 1.
DR   TIGRFAMs; TIGR00769; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..507
FT                   /note="ADP,ATP carrier protein 2"
FT                   /id="PRO_0000286471"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   507 AA;  58374 MW;  B8895F62706AB8F1 CRC64;
     MNIVDSNCTI WHKARNSKFR HIVWPIRSYE LTKFIPMALL MFFILLNQNL VRSLKDSFVV
     TLISSEVLSF IKLWGEMPMG VLFVILYSKL CNIMTTEQVF RIITGTFLFF FTIFGFILFP
     YKEFFHPDPE LINQYITVLP HLKWFLIIWG QWSLVLFYIM GELWPVIVFT LLYWQLANKI
     TKVEEAPRFY SFFTLFGQTN LLFSGTVIIY FAKSEHFLLP LFAHLNDTNE ILLKSFITVI
     LLSGLICLAL HKLIDKSVVE ADKNIKFKNQ RTDILKLSLI ESAKIILTSR YLGFICLLVM
     SYSMSINLIE GLWMSKVKQL YPATKDFISY HGEVLFWTGV LTLVSAFLGS SLIRIYGWFW
     GAIITPIMMF VAGVIFFSFT IFENHLGNIV NTLGYSSPLV IIVFIGGLWH VFSKSVKYSL
     FDATKEMVYI PLDNEIKTKG KAAVDVIGAK IGKSIGAVIQ FISFSIFPNA VHNDIAGLLM
     FTFIIVCILW IYGVKVLSQY NNKMIQN