ID   TLCD2_DANRE             Reviewed;         246 AA.
AC   A8WGS4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=TLC domain-containing protein 2;
GN   Name=tlcd2; ORFNames=zgc:175098;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the composition and fluidity of the plasma membrane
CC       (By similarity). Inhibits the incorporation of membrane-fluidizing
CC       phospholipids containing omega-3 long-chain polyunsaturated fatty acids
CC       (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does
CC       not appear to have any effect on LCPUFA synthesis (By similarity).
CC       {ECO:0000250|UniProtKB:A6NGC4}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A6NGC4};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TLCD family. {ECO:0000305}.
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DR   EMBL; BC154828; AAI54829.1; -; mRNA.
DR   RefSeq; NP_001103852.1; NM_001110382.1.
DR   AlphaFoldDB; A8WGS4; -.
DR   STRING; 7955.ENSDARP00000099595; -.
DR   PaxDb; A8WGS4; -.
DR   Ensembl; ENSDART00000112079; ENSDARP00000099595; ENSDARG00000077396.
DR   GeneID; 559420; -.
DR   KEGG; dre:559420; -.
DR   CTD; 727910; -.
DR   ZFIN; ZDB-GENE-080204-81; tlcd2.
DR   eggNOG; KOG4474; Eukaryota.
DR   GeneTree; ENSGT01010000222313; -.
DR   HOGENOM; CLU_056440_2_1_1; -.
DR   InParanoid; A8WGS4; -.
DR   OMA; VSCRYVG; -.
DR   OrthoDB; 1113854at2759; -.
DR   PhylomeDB; A8WGS4; -.
DR   TreeFam; TF315115; -.
DR   PRO; PR:A8WGS4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 15.
DR   Bgee; ENSDARG00000077396; Expressed in intestine and 25 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   GO; GO:0071709; P:membrane assembly; IBA:GO_Central.
DR   GO; GO:0055091; P:phospholipid homeostasis; IBA:GO_Central.
DR   GO; GO:0007009; P:plasma membrane organization; IBA:GO_Central.
DR   GO; GO:0097035; P:regulation of membrane lipid distribution; IBA:GO_Central.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..246
FT                   /note="TLC domain-containing protein 2"
FT                   /id="PRO_0000328992"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          35..231
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   246 AA;  28334 MW;  8C6B1A897A7C2968 CRC64;
     MELNSVILTT GSSVGFFKLV NYGLGKLPIP ETARRNAWKW NNISTSFVHS LITGVWSVLC
     FCMHPQMAED LIETHSVFSH ALVSVSIGYF IYDFLDMVIN QKIIHSWELL FHHVVVITCF
     GISVLTCRYV GFAVVALLVE INSVFLHLRQ VLRMANLAKS TFYRVNSMIN LGTYVVFRIN
     TLAWMTRWLV LNRDLIPLFS YTIGSVGLAI MTAMNIVLFY RLMRSDFMKA SREKELRKEK
     EKEKDM