TLCD2_HUMAN
ID TLCD2_HUMAN Reviewed; 264 AA.
AC A6NGC4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 3.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=TLC domain-containing protein 2;
GN Name=TLCD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=30509349; DOI=10.7554/elife.40686;
RA Ruiz M., Bodhicharla R., Svensk E., Devkota R., Busayavalasa K.,
RA Palmgren H., Staahlman M., Boren J., Pilon M.;
RT "Membrane fluidity is regulated by the C. elegans transmembrane protein
RT FLD-1 and its human homologs TLCD1/2.";
RL Elife 7:0-0(2018).
CC -!- FUNCTION: Regulates the composition and fluidity of the plasma membrane
CC (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing
CC phospholipids containing omega-3 long-chain polyunsaturated fatty acids
CC (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does
CC not appear to have any effect on LCPUFA synthesis (PubMed:30509349).
CC {ECO:0000269|PubMed:30509349}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:30509349};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TLCD family. {ECO:0000305}.
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DR EMBL; AC130343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45567.1; -.
DR RefSeq; NP_001157879.1; NM_001164407.1.
DR AlphaFoldDB; A6NGC4; -.
DR BioGRID; 608350; 10.
DR IntAct; A6NGC4; 2.
DR STRING; 9606.ENSP00000331965; -.
DR iPTMnet; A6NGC4; -.
DR PhosphoSitePlus; A6NGC4; -.
DR BioMuta; TLCD2; -.
DR EPD; A6NGC4; -.
DR jPOST; A6NGC4; -.
DR MassIVE; A6NGC4; -.
DR PaxDb; A6NGC4; -.
DR PeptideAtlas; A6NGC4; -.
DR PRIDE; A6NGC4; -.
DR ProteomicsDB; 1116; -.
DR Antibodypedia; 62302; 58 antibodies from 12 providers.
DR DNASU; 727910; -.
DR Ensembl; ENST00000330676.8; ENSP00000331965.6; ENSG00000185561.10.
DR Ensembl; ENST00000611774.2; ENSP00000479301.1; ENSG00000275246.2.
DR GeneID; 727910; -.
DR KEGG; hsa:727910; -.
DR MANE-Select; ENST00000330676.8; ENSP00000331965.6; NM_001164407.2; NP_001157879.1.
DR UCSC; uc021tnh.2; human.
DR CTD; 727910; -.
DR DisGeNET; 727910; -.
DR GeneCards; TLCD2; -.
DR HGNC; HGNC:33522; TLCD2.
DR HPA; ENSG00000185561; Low tissue specificity.
DR neXtProt; NX_A6NGC4; -.
DR OpenTargets; ENSG00000185561; -.
DR PharmGKB; PA162405795; -.
DR VEuPathDB; HostDB:ENSG00000185561; -.
DR eggNOG; KOG4474; Eukaryota.
DR GeneTree; ENSGT01010000222313; -.
DR HOGENOM; CLU_056440_2_1_1; -.
DR InParanoid; A6NGC4; -.
DR OMA; VSCRYVG; -.
DR OrthoDB; 1113854at2759; -.
DR PhylomeDB; A6NGC4; -.
DR TreeFam; TF315115; -.
DR PathwayCommons; A6NGC4; -.
DR SignaLink; A6NGC4; -.
DR BioGRID-ORCS; 727910; 11 hits in 1075 CRISPR screens.
DR ChiTaRS; TLCD2; human.
DR GenomeRNAi; 727910; -.
DR Pharos; A6NGC4; Tdark.
DR PRO; PR:A6NGC4; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NGC4; protein.
DR Bgee; ENSG00000185561; Expressed in mucosa of transverse colon and 96 other tissues.
DR Genevisible; A6NGC4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR GO; GO:0071709; P:membrane assembly; IMP:UniProtKB.
DR GO; GO:0055091; P:phospholipid homeostasis; IMP:UniProtKB.
DR GO; GO:0007009; P:plasma membrane organization; IMP:UniProtKB.
DR GO; GO:0097035; P:regulation of membrane lipid distribution; IMP:UniProtKB.
DR InterPro; IPR006634; TLC-dom.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..264
FT /note="TLC domain-containing protein 2"
FT /id="PRO_0000328990"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 34..227
FT /note="TLC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
FT REGION 230..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 28733 MW; E2B4B93612BCC33A CRC64;
MAPTGLLVAG ASFLAFRGLH WGLRRLPTPE SAARDRWQWW NLCVSLAHSL LSGTGALLGL
SLYPQMAADP IHGHPRWALV LVAVSVGYFL ADGADLLWNQ TLGKTWDLLC HHLVVVSCLS
TAVLSGHYVG FSMVSLLLEL NSACLHLRKL LLLSRQAPSL AFSVTSWASL ATLALFRLVP
LGWMSLWLFR QHHQVPLALV TLGGIGLVTV GIMSIILGIR ILVNDVLQSR PHPPSPGHEK
TRGTRTRRDN GPVTSNSSTL SLKD
