TLCD4_HUMAN
ID TLCD4_HUMAN Reviewed; 263 AA.
AC Q96MV1; B2RPI2; D3DT48;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=TLC domain-containing protein 4 {ECO:0000305};
DE AltName: Full=Transmembrane protein 56;
GN Name=TLCD4 {ECO:0000312|HGNC:HGNC:26477}; Synonyms=TMEM56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
CC -!- INTERACTION:
CC Q96MV1; O60242: ADGRB3; NbExp=3; IntAct=EBI-12947623, EBI-2682765;
CC Q96MV1; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-12947623, EBI-11277970;
CC Q96MV1; Q9H2C2: ARV1; NbExp=3; IntAct=EBI-12947623, EBI-11724186;
CC Q96MV1; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-12947623, EBI-12069500;
CC Q96MV1; Q12983: BNIP3; NbExp=3; IntAct=EBI-12947623, EBI-749464;
CC Q96MV1; Q06432: CACNG1; NbExp=3; IntAct=EBI-12947623, EBI-9686780;
CC Q96MV1; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-12947623, EBI-9083477;
CC Q96MV1; O14735: CDIPT; NbExp=3; IntAct=EBI-12947623, EBI-358858;
CC Q96MV1; Q8WUD6: CHPT1; NbExp=3; IntAct=EBI-12947623, EBI-11337856;
CC Q96MV1; P51798: CLCN7; NbExp=3; IntAct=EBI-12947623, EBI-4402346;
CC Q96MV1; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-12947623, EBI-11989440;
CC Q96MV1; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-12947623, EBI-11522780;
CC Q96MV1; P21964: COMT; NbExp=3; IntAct=EBI-12947623, EBI-372265;
CC Q96MV1; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-12947623, EBI-12019274;
CC Q96MV1; P78329: CYP4F2; NbExp=3; IntAct=EBI-12947623, EBI-1752413;
CC Q96MV1; Q6NT55: CYP4F22; NbExp=3; IntAct=EBI-12947623, EBI-17509525;
CC Q96MV1; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-12947623, EBI-3923585;
CC Q96MV1; Q15125: EBP; NbExp=3; IntAct=EBI-12947623, EBI-3915253;
CC Q96MV1; Q9BV81: EMC6; NbExp=3; IntAct=EBI-12947623, EBI-2820492;
CC Q96MV1; P54849: EMP1; NbExp=3; IntAct=EBI-12947623, EBI-4319440;
CC Q96MV1; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-12947623, EBI-711490;
CC Q96MV1; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-12947623, EBI-11337888;
CC Q96MV1; P37268: FDFT1; NbExp=3; IntAct=EBI-12947623, EBI-714550;
CC Q96MV1; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-12947623, EBI-713304;
CC Q96MV1; P29033: GJB2; NbExp=3; IntAct=EBI-12947623, EBI-3905204;
CC Q96MV1; O14653: GOSR2; NbExp=3; IntAct=EBI-12947623, EBI-4401517;
CC Q96MV1; P02724: GYPA; NbExp=3; IntAct=EBI-12947623, EBI-702665;
CC Q96MV1; P09601: HMOX1; NbExp=3; IntAct=EBI-12947623, EBI-2806151;
CC Q96MV1; P24593: IGFBP5; NbExp=3; IntAct=EBI-12947623, EBI-720480;
CC Q96MV1; P04264: KRT1; NbExp=3; IntAct=EBI-12947623, EBI-298429;
CC Q96MV1; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-12947623, EBI-12133176;
CC Q96MV1; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-12947623, EBI-12070086;
CC Q96MV1; Q9HB07: MYG1; NbExp=3; IntAct=EBI-12947623, EBI-709754;
CC Q96MV1; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-12947623, EBI-2863634;
CC Q96MV1; O95167: NDUFA3; NbExp=3; IntAct=EBI-12947623, EBI-1246131;
CC Q96MV1; Q92982: NINJ1; NbExp=3; IntAct=EBI-12947623, EBI-2802124;
CC Q96MV1; Q16617: NKG7; NbExp=3; IntAct=EBI-12947623, EBI-3919611;
CC Q96MV1; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-12947623, EBI-1054848;
CC Q96MV1; Q01453: PMP22; NbExp=3; IntAct=EBI-12947623, EBI-2845982;
CC Q96MV1; O60831: PRAF2; NbExp=3; IntAct=EBI-12947623, EBI-2506064;
CC Q96MV1; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-12947623, EBI-722696;
CC Q96MV1; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-12947623, EBI-14065960;
CC Q96MV1; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-12947623, EBI-2695784;
CC Q96MV1; O00767: SCD; NbExp=3; IntAct=EBI-12947623, EBI-2684237;
CC Q96MV1; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-12947623, EBI-8652744;
CC Q96MV1; O75396: SEC22B; NbExp=3; IntAct=EBI-12947623, EBI-1058865;
CC Q96MV1; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-12947623, EBI-10329948;
CC Q96MV1; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-12947623, EBI-355861;
CC Q96MV1; A0A1P0AYU5: SFXN3; NbExp=3; IntAct=EBI-12947623, EBI-14193895;
CC Q96MV1; Q96BI1: SLC22A18; NbExp=3; IntAct=EBI-12947623, EBI-11721845;
CC Q96MV1; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-12947623, EBI-12266234;
CC Q96MV1; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-12947623, EBI-10226799;
CC Q96MV1; P02808: STATH; NbExp=3; IntAct=EBI-12947623, EBI-738687;
CC Q96MV1; Q86Y82: STX12; NbExp=3; IntAct=EBI-12947623, EBI-2691717;
CC Q96MV1; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-12947623, EBI-726331;
CC Q96MV1; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-12947623, EBI-1049004;
CC Q96MV1; O14925: TIMM23; NbExp=3; IntAct=EBI-12947623, EBI-1047996;
CC Q96MV1; Q12893: TMEM115; NbExp=3; IntAct=EBI-12947623, EBI-8633987;
CC Q96MV1; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-12947623, EBI-10171534;
CC Q96MV1; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-12947623, EBI-741829;
CC Q96MV1; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-12947623, EBI-12195227;
CC Q96MV1; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12947623, EBI-10982110;
CC Q96MV1; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-12947623, EBI-2852148;
CC Q96MV1; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-12947623, EBI-11343401;
CC Q96MV1; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-12947623, EBI-988826;
CC Q96MV1; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-12947623, EBI-7850136;
CC Q96MV1; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-12947623, EBI-751253;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}.
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DR EMBL; AK056404; BAB71177.1; -; mRNA.
DR EMBL; CH471097; EAW73024.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW73025.1; -; Genomic_DNA.
DR EMBL; BC137457; AAI37458.1; -; mRNA.
DR EMBL; BC137458; AAI37459.1; -; mRNA.
DR EMBL; BC139737; AAI39738.1; -; mRNA.
DR CCDS; CCDS753.1; -.
DR RefSeq; NP_001186608.1; NM_001199679.1.
DR RefSeq; NP_689700.1; NM_152487.2.
DR AlphaFoldDB; Q96MV1; -.
DR BioGRID; 127154; 104.
DR IntAct; Q96MV1; 81.
DR STRING; 9606.ENSP00000359222; -.
DR CarbonylDB; Q96MV1; -.
DR iPTMnet; Q96MV1; -.
DR PhosphoSitePlus; Q96MV1; -.
DR BioMuta; TMEM56; -.
DR DMDM; 74732443; -.
DR jPOST; Q96MV1; -.
DR MassIVE; Q96MV1; -.
DR MaxQB; Q96MV1; -.
DR PaxDb; Q96MV1; -.
DR PeptideAtlas; Q96MV1; -.
DR PRIDE; Q96MV1; -.
DR ProteomicsDB; 77418; -.
DR Antibodypedia; 71812; 53 antibodies from 8 providers.
DR DNASU; 148534; -.
DR Ensembl; ENST00000370203.9; ENSP00000359222.4; ENSG00000152078.10.
DR GeneID; 148534; -.
DR KEGG; hsa:148534; -.
DR MANE-Select; ENST00000370203.9; ENSP00000359222.4; NM_152487.3; NP_689700.1.
DR UCSC; uc001drb.4; human.
DR CTD; 148534; -.
DR DisGeNET; 148534; -.
DR GeneCards; TLCD4; -.
DR HGNC; HGNC:26477; TLCD4.
DR HPA; ENSG00000152078; Tissue enriched (liver).
DR neXtProt; NX_Q96MV1; -.
DR OpenTargets; ENSG00000152078; -.
DR VEuPathDB; HostDB:ENSG00000152078; -.
DR eggNOG; KOG4561; Eukaryota.
DR GeneTree; ENSGT01010000222313; -.
DR HOGENOM; CLU_034597_2_0_1; -.
DR InParanoid; Q96MV1; -.
DR OMA; YYGRMYA; -.
DR OrthoDB; 1354968at2759; -.
DR PhylomeDB; Q96MV1; -.
DR TreeFam; TF324847; -.
DR PathwayCommons; Q96MV1; -.
DR SignaLink; Q96MV1; -.
DR BioGRID-ORCS; 148534; 11 hits in 1067 CRISPR screens.
DR GenomeRNAi; 148534; -.
DR Pharos; Q96MV1; Tdark.
DR PRO; PR:Q96MV1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96MV1; protein.
DR Bgee; ENSG00000152078; Expressed in left ventricle myocardium and 170 other tissues.
DR ExpressionAtlas; Q96MV1; baseline and differential.
DR Genevisible; Q96MV1; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR InterPro; IPR006634; TLC-dom.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..263
FT /note="TLC domain-containing protein 4"
FT /id="PRO_0000286701"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 44..246
FT /note="TLC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
FT MOD_RES 165
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
SQ SEQUENCE 263 AA; 30041 MW; 51480330FACC8ABF CRC64;
MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN SRVVSTCHSL
VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI SDLSIIILYW KVIGDKFFIM
HHCASLYAYY LVLKNGVLAY IGNFRLLAEL SSPFVNQRWF FEALKYPKFS KAIVINGILM
TVVFFIVRIA SMLPHYGFMY SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG
CIKVISHIRQ EKAKNSLQNG KLD
