TLCD4_MOUSE
ID TLCD4_MOUSE Reviewed; 276 AA.
AC Q8CGF5; Q9D4Q8;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=TLC domain-containing protein 4 {ECO:0000305};
DE AltName: Full=Transmembrane protein 56;
GN Name=Tlcd4; Synonyms=Tmem56;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Liver tumor, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CGF5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CGF5-2; Sequence=VSP_025144, VSP_025145;
CC -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-14 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK016295; BAB30181.1; -; mRNA.
DR EMBL; AK147601; BAE28017.1; -; mRNA.
DR EMBL; AK149544; BAE28949.1; -; mRNA.
DR EMBL; BC040365; AAH40365.1; -; mRNA.
DR RefSeq; NP_849267.1; NM_178936.3.
DR RefSeq; XP_006502540.1; XM_006502477.2.
DR RefSeq; XP_006502541.1; XM_006502478.2. [Q8CGF5-1]
DR RefSeq; XP_006502543.1; XM_006502480.3. [Q8CGF5-1]
DR RefSeq; XP_011238639.1; XM_011240337.1. [Q8CGF5-1]
DR RefSeq; XP_011238641.1; XM_011240339.1. [Q8CGF5-1]
DR RefSeq; XP_011238642.1; XM_011240340.1. [Q8CGF5-1]
DR AlphaFoldDB; Q8CGF5; -.
DR IntAct; Q8CGF5; 1.
DR MINT; Q8CGF5; -.
DR STRING; 10090.ENSMUSP00000029777; -.
DR iPTMnet; Q8CGF5; -.
DR PhosphoSitePlus; Q8CGF5; -.
DR jPOST; Q8CGF5; -.
DR MaxQB; Q8CGF5; -.
DR PaxDb; Q8CGF5; -.
DR PRIDE; Q8CGF5; -.
DR ProteomicsDB; 259131; -. [Q8CGF5-1]
DR ProteomicsDB; 259132; -. [Q8CGF5-2]
DR Antibodypedia; 71812; 53 antibodies from 8 providers.
DR Ensembl; ENSMUST00000029777; ENSMUSP00000029777; ENSMUSG00000028132. [Q8CGF5-1]
DR Ensembl; ENSMUST00000128909; ENSMUSP00000119468; ENSMUSG00000028132. [Q8CGF5-1]
DR Ensembl; ENSMUST00000135818; ENSMUSP00000114755; ENSMUSG00000028132. [Q8CGF5-2]
DR Ensembl; ENSMUST00000155309; ENSMUSP00000120821; ENSMUSG00000028132. [Q8CGF5-1]
DR GeneID; 99887; -.
DR KEGG; mmu:99887; -.
DR UCSC; uc008rdt.1; mouse. [Q8CGF5-2]
DR UCSC; uc008rdu.1; mouse. [Q8CGF5-1]
DR CTD; 148534; -.
DR MGI; MGI:1923195; Tlcd4.
DR VEuPathDB; HostDB:ENSMUSG00000028132; -.
DR eggNOG; KOG4561; Eukaryota.
DR GeneTree; ENSGT01010000222313; -.
DR HOGENOM; CLU_034597_2_0_1; -.
DR InParanoid; Q8CGF5; -.
DR OMA; YYGRMYA; -.
DR OrthoDB; 1354968at2759; -.
DR PhylomeDB; Q8CGF5; -.
DR TreeFam; TF324847; -.
DR BioGRID-ORCS; 99887; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem56; mouse.
DR PRO; PR:Q8CGF5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8CGF5; protein.
DR Bgee; ENSMUSG00000028132; Expressed in pigmented layer of retina and 222 other tissues.
DR ExpressionAtlas; Q8CGF5; baseline and differential.
DR Genevisible; Q8CGF5; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR InterPro; IPR006634; TLC-dom.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..276
FT /note="TLC domain-containing protein 4"
FT /id="PRO_0000286702"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 57..259
FT /note="TLC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
FT MOD_RES 178
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q96MV1"
FT VAR_SEQ 224..231
FT /note="FGFVIQSV -> TCILKVNF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025144"
FT VAR_SEQ 232..276
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025145"
SQ SEQUENCE 276 AA; 31236 MW; FDAA29987C68DCAC CRC64;
MEASTKAAVG SGAMEASTKA VICTVCSSFV VFQILFHFVS YWFSARVSSG YNSLSIDKKI
EWNSRVVSTC HSLLVGIFGL YLFFFDEATI TDPLWGDPTY VNINIATASG YLISDLLIIL
FNWKVIGDKF FIIHHCAGLT AYYFVLTTGA LAYIANFRLL AELSSPFVNQ RWFFEALKYP
KFSKANVING ILMTVVFFIV RIISIPPMYF FLYSVYGTEP YIRFGFVIQS VWIVTCVILD
VMNIMWMIKI TKGCIKVISL IRQEKAKDSL QNGKLD
