ID   TLCD4_XENTR             Reviewed;         259 AA.
AC   Q6P4N1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=TLC domain-containing protein 4;
DE   AltName: Full=Transmembrane protein 56;
GN   Name=tlcd4; Synonyms=tmem56;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TLCD4 family. {ECO:0000305}.
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DR   EMBL; BC063336; AAH63336.1; -; mRNA.
DR   RefSeq; NP_989182.1; NM_203851.1.
DR   AlphaFoldDB; Q6P4N1; -.
DR   STRING; 8364.ENSXETP00000036495; -.
DR   PaxDb; Q6P4N1; -.
DR   DNASU; 394789; -.
DR   GeneID; 394789; -.
DR   KEGG; xtr:394789; -.
DR   CTD; 394789; -.
DR   Xenbase; XB-GENE-5756243; tlcd4.2.
DR   eggNOG; KOG4561; Eukaryota.
DR   HOGENOM; CLU_034597_2_0_1; -.
DR   InParanoid; Q6P4N1; -.
DR   OMA; HANNHTD; -.
DR   OrthoDB; 1354968at2759; -.
DR   PhylomeDB; Q6P4N1; -.
DR   TreeFam; TF324847; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016736; Expressed in liver and 11 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..259
FT                   /note="TLC domain-containing protein 4"
FT                   /id="PRO_0000286706"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          44..246
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   259 AA;  29644 MW;  E59AADAF13888FDA CRC64;
     MDDSVFISYC VVTGSFLGFQ LLFSIISPRT FTKYSSTYRQ LSFGKQCEWD SRCVSTTHAL
     VVGSGCLYIL AYDEAVNADP IWGDPFWVKM NVAITCGYLV HDLLLLARFW KVMRDPYMVC
     HHLAVFYSYG YVLNRGVLPY FANFRLISEL STPFVNQRWF FDVIGKPRSS WPVLLNGLAM
     ALVFFIVRIA VIPSYYSQVF ATFGTEGYIR LGIGPQVAWI VSCVVLDILN VFWMYKIARG
     FYKVVKAKPD GKPRRNHAD