ID   TLCD5_BOVIN             Reviewed;         245 AA.
AC   Q0VD42;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=TLC domain-containing protein 5 {ECO:0000305};
DE   AltName: Full=Transmembrane protein 136;
GN   Name=TLCD5; Synonyms=TMEM136;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TLCD5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC119842; AAI19843.1; -; mRNA.
DR   RefSeq; NP_001069274.1; NM_001075806.1.
DR   RefSeq; XP_005216015.1; XM_005215958.3.
DR   RefSeq; XP_005216017.1; XM_005215960.3.
DR   RefSeq; XP_005216018.1; XM_005215961.3.
DR   RefSeq; XP_005216019.1; XM_005215962.3.
DR   AlphaFoldDB; Q0VD42; -.
DR   STRING; 9913.ENSBTAP00000039814; -.
DR   PaxDb; Q0VD42; -.
DR   Ensembl; ENSBTAT00000040031; ENSBTAP00000039814; ENSBTAG00000021342.
DR   GeneID; 520468; -.
DR   KEGG; bta:520468; -.
DR   CTD; 219902; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021342; -.
DR   VGNC; VGNC:35970; TLCD5.
DR   eggNOG; KOG4474; Eukaryota.
DR   GeneTree; ENSGT00390000008162; -.
DR   HOGENOM; CLU_083447_0_0_1; -.
DR   InParanoid; Q0VD42; -.
DR   OMA; WLSLYTW; -.
DR   OrthoDB; 1353190at2759; -.
DR   TreeFam; TF329126; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000021342; Expressed in retina and 90 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006634; TLC-dom.
DR   InterPro; IPR042512; TLCD5.
DR   PANTHER; PTHR31898; PTHR31898; 1.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..245
FT                   /note="TLC domain-containing protein 5"
FT                   /id="PRO_0000285582"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          29..204
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ   SEQUENCE   245 AA;  27957 MW;  9424878446909AFE CRC64;
     MALALCLQAL CSLGGWLSLY VSFCRLNKHR SYEWNCRLVT FTHGILSIGL SAYIGFIDGP
     WPFTHPGSPN TPLQVHVLCL TLGYFIFDLG WCIYFRSEGP LMLAHHTLSI LGIIVALVLG
     ESGTEVNAVL FGSEITNPLL QIRWFLRETG HYHSFTGDVV DFLFVALFTG VRIGVGACLL
     FCEMVSPTPK WFVKVGGVAM YVVSWCFMFS IWRFAWRKSI KKYHTWRSRW SEERQLRLNG
     HLKTH