TLCD5_DANRE
ID TLCD5_DANRE Reviewed; 242 AA.
AC Q1LXV8; Q6DH71;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=TLC domain-containing protein 5 {ECO:0000305};
DE AltName: Full=Transmembrane protein 136;
GN Name=tlcd5; Synonyms=tmem136; ORFNames=si:dkey-70k11.2, zgc:92621;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TLCD5 family. {ECO:0000305}.
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DR EMBL; BX248506; CAK11151.1; -; Genomic_DNA.
DR EMBL; BC076110; AAH76110.1; -; mRNA.
DR RefSeq; NP_001002701.1; NM_001002701.1.
DR AlphaFoldDB; Q1LXV8; -.
DR STRING; 7955.ENSDARP00000050931; -.
DR PaxDb; Q1LXV8; -.
DR Ensembl; ENSDART00000050932; ENSDARP00000050931; ENSDARG00000035163.
DR GeneID; 436974; -.
DR KEGG; dre:436974; -.
DR CTD; 436974; -.
DR ZFIN; ZDB-GENE-040718-455; tlcd5b.
DR eggNOG; KOG4474; Eukaryota.
DR GeneTree; ENSGT00390000008162; -.
DR HOGENOM; CLU_083447_0_0_1; -.
DR InParanoid; Q1LXV8; -.
DR OMA; WLSLYTW; -.
DR OrthoDB; 1353190at2759; -.
DR PhylomeDB; Q1LXV8; -.
DR TreeFam; TF329126; -.
DR PRO; PR:Q1LXV8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000035163; Expressed in retina and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006634; TLC-dom.
DR InterPro; IPR042512; TLCD5.
DR PANTHER; PTHR31898; PTHR31898; 1.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..242
FT /note="TLC domain-containing protein 5"
FT /id="PRO_0000285585"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 28..219
FT /note="TLC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
FT CONFLICT 228
FT /note="Q -> R (in Ref. 2; AAH76110)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 242 AA; 27305 MW; 9657EE4D46C1F042 CRC64;
MPLFIVETSC SLISWLFLYL LLCHLNSGRD SEWNCRLVTL FHGILIICLT AYIGFIAGPW
PFTHPGTENT YFQILTLVLS LGYFLFDMAW CVYFRTEGPV MLAHHTMSIF GILLALGLGE
SGIETCAVLF GSEITNPLLQ ARWFLKRMGC YDSLAGDVVD LLFILLFASV RIGVGSRMLY
CELTSPKPSL IVKVGGVAIY TLSWIFMVDI ARFACRKTCG KYRRWKEQYK LDGVNGHAVK
IK
