TLCD5_MOUSE
ID TLCD5_MOUSE Reviewed; 245 AA.
AC Q3TYE7; B9EI43;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=TLC domain-containing protein 5 {ECO:0000305};
DE AltName: Full=Transmembrane protein 136;
GN Name=Tlcd5; Synonyms=Gm184, Tmem136;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TLCD5 family. {ECO:0000305}.
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DR EMBL; AK158698; BAE34616.1; -; mRNA.
DR EMBL; BC139047; AAI39048.1; -; mRNA.
DR CCDS; CCDS23090.1; -.
DR RefSeq; NP_001030035.1; NM_001034863.3.
DR RefSeq; XP_006510319.1; XM_006510256.1.
DR AlphaFoldDB; Q3TYE7; -.
DR STRING; 10090.ENSMUSP00000051435; -.
DR PaxDb; Q3TYE7; -.
DR PRIDE; Q3TYE7; -.
DR Antibodypedia; 71703; 17 antibodies from 9 providers.
DR Ensembl; ENSMUST00000061833; ENSMUSP00000051435; ENSMUSG00000048503.
DR Ensembl; ENSMUST00000213544; ENSMUSP00000150692; ENSMUSG00000048503.
DR GeneID; 235300; -.
DR KEGG; mmu:235300; -.
DR UCSC; uc009pbd.1; mouse.
DR CTD; 219902; -.
DR MGI; MGI:2685030; Tlcd5.
DR VEuPathDB; HostDB:ENSMUSG00000048503; -.
DR eggNOG; KOG4474; Eukaryota.
DR GeneTree; ENSGT00390000008162; -.
DR HOGENOM; CLU_083447_0_0_1; -.
DR InParanoid; Q3TYE7; -.
DR OMA; WLSLYTW; -.
DR OrthoDB; 1353190at2759; -.
DR PhylomeDB; Q3TYE7; -.
DR TreeFam; TF329126; -.
DR BioGRID-ORCS; 235300; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Tmem136; mouse.
DR PRO; PR:Q3TYE7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3TYE7; protein.
DR Bgee; ENSMUSG00000048503; Expressed in pigmented layer of retina and 192 other tissues.
DR ExpressionAtlas; Q3TYE7; baseline and differential.
DR Genevisible; Q3TYE7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006634; TLC-dom.
DR InterPro; IPR042512; TLCD5.
DR PANTHER; PTHR31898; PTHR31898; 1.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..245
FT /note="TLC domain-containing protein 5"
FT /id="PRO_0000285584"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 29..204
FT /note="TLC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
SQ SEQUENCE 245 AA; 27705 MW; 2727C9DC307CFC67 CRC64;
MAVGLCVQVL CSLGGWLSLY TSFCCLNKHR SCEWSCRLVT FTHGVLSIGL SAYIGFIDGP
WPFTHPGSPN TPLQVHVLCL TLGYFIFDLG WCIYFQSEGP LMLAHHTLSI LGIIMALALG
ESGTEVNAVL FGSEITNPLL QMRWFLRETG HYHSFTGDVV DFLFVALFTG VRIGVGAHLL
FCEMVSPTPK WFVKVGGVAM YAVSWCFMVS IWRFAWKKSI KKYHAWRSRR NEERQLRHNG
HLKTH
