BSPH1_HUMAN
ID BSPH1_HUMAN Reviewed; 132 AA.
AC Q075Z2; A6NIZ5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Binder of sperm protein homolog 1;
DE AltName: Full=Bovine seminal plasma protein homolog 1;
DE AltName: Full=Bovine seminal plasma protein-like 1;
DE Flags: Precursor;
GN Name=BSPH1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Epididymis;
RX PubMed=17085770; DOI=10.1093/molehr/gal098;
RA Lefebvre J., Fan J., Chevalier S., Sullivan R., Carmona E., Manjunath P.;
RT "Genomic structure and tissue-specific expression of human and mouse genes
RT encoding homologues of the major bovine seminal plasma proteins.";
RL Mol. Hum. Reprod. 13:45-53(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: Binds sperm in vitro and promotes sperm capacitation.
CC Specifically promotes capacitation induced by high density lipoproteins
CC (HDLs). Also binds heparin, phospholipid liposomes, and weakly to
CC gelatin. Does not bind chondroitin sulfate B.
CC {ECO:0000250|UniProtKB:Q3UW26}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed only in the epididymis.
CC {ECO:0000269|PubMed:17085770}.
CC -!- SIMILARITY: Belongs to the seminal plasma protein family.
CC {ECO:0000305}.
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DR EMBL; DQ227497; ABB71591.1; -; mRNA.
DR EMBL; AC010330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46135.1; -.
DR RefSeq; NP_001121798.1; NM_001128326.2.
DR RefSeq; XP_016881607.1; XM_017026118.1.
DR AlphaFoldDB; Q075Z2; -.
DR SMR; Q075Z2; -.
DR STRING; 9606.ENSP00000341762; -.
DR GlyGen; Q075Z2; 1 site.
DR iPTMnet; Q075Z2; -.
DR PhosphoSitePlus; Q075Z2; -.
DR BioMuta; BSPH1; -.
DR DMDM; 121939964; -.
DR MassIVE; Q075Z2; -.
DR PaxDb; Q075Z2; -.
DR PeptideAtlas; Q075Z2; -.
DR PRIDE; Q075Z2; -.
DR ProteomicsDB; 58519; -.
DR Antibodypedia; 70932; 4 antibodies from 4 providers.
DR DNASU; 100131137; -.
DR Ensembl; ENST00000344839.3; ENSP00000341762.3; ENSG00000188334.3.
DR GeneID; 100131137; -.
DR KEGG; hsa:100131137; -.
DR MANE-Select; ENST00000344839.3; ENSP00000341762.3; NM_001128326.2; NP_001121798.1.
DR UCSC; uc002phs.1; human.
DR CTD; 100131137; -.
DR DisGeNET; 100131137; -.
DR GeneCards; BSPH1; -.
DR HGNC; HGNC:33906; BSPH1.
DR HPA; ENSG00000188334; Tissue enriched (epididymis).
DR MIM; 612213; gene.
DR neXtProt; NX_Q075Z2; -.
DR OpenTargets; ENSG00000188334; -.
DR PharmGKB; PA164716709; -.
DR VEuPathDB; HostDB:ENSG00000188334; -.
DR eggNOG; KOG1565; Eukaryota.
DR GeneTree; ENSGT00940000163003; -.
DR HOGENOM; CLU_126630_1_0_1; -.
DR InParanoid; Q075Z2; -.
DR OMA; CIKSKSR; -.
DR OrthoDB; 1429125at2759; -.
DR PhylomeDB; Q075Z2; -.
DR TreeFam; TF343543; -.
DR PathwayCommons; Q075Z2; -.
DR BioGRID-ORCS; 100131137; 15 hits in 1061 CRISPR screens.
DR GenomeRNAi; 100131137; -.
DR Pharos; Q075Z2; Tdark.
DR PRO; PR:Q075Z2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q075Z2; protein.
DR Bgee; ENSG00000188334; Expressed in right hemisphere of cerebellum and 12 other tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR GO; GO:0048240; P:sperm capacitation; IBA:GO_Central.
DR CDD; cd00062; FN2; 1.
DR Gene3D; 2.10.10.10; -; 2.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR Pfam; PF00040; fn2; 2.
DR SMART; SM00059; FN2; 2.
DR SUPFAM; SSF57440; SSF57440; 2.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Fertilization; Glycoprotein; Reference proteome; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..132
FT /note="Binder of sperm protein homolog 1"
FT /id="PRO_0000326156"
FT DOMAIN 40..84
FT /note="Fibronectin type-II 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DOMAIN 85..132
FT /note="Fibronectin type-II 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DISULFID 59..82
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DISULFID 90..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DISULFID 104..131
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 132 AA; 15693 MW; 5B65371C8AB140CC CRC64;
MGSLMLLFVE TTRNSSACIF PVILNELSST VETITHFPEV TDGECVFPFH YKNGTYYDCI
KSKARHKWCS LNKTYEGYWK FCSAEDFANC VFPFWYRRLI YWECTDDGEA FGKKWCSLTK
NFNKDRIWKY CE
