ID   TLCD_RICPR              Reviewed;         512 AA.
AC   Q9ZD47;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=ADP,ATP carrier protein 4;
DE   AltName: Full=ADP/ATP translocase 4;
GN   Name=tlcD; Synonyms=tlc4; OrderedLocusNames=RP500;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235272; CAA14952.1; -; Genomic_DNA.
DR   PIR; F71653; F71653.
DR   RefSeq; NP_220876.1; NC_000963.1.
DR   RefSeq; WP_004597746.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZD47; -.
DR   STRING; 272947.RP500; -.
DR   TCDB; 2.A.12.1.4; the atp:adp antiporter (aaa) family.
DR   EnsemblBacteria; CAA14952; CAA14952; CAA14952.
DR   GeneID; 57569623; -.
DR   KEGG; rpr:RP500; -.
DR   PATRIC; fig|272947.5.peg.509; -.
DR   eggNOG; COG3202; Bacteria.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OMA; FLMTAIY; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   GO; GO:0015931; P:nucleobase-containing compound transport; IDA:CACAO.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   PANTHER; PTHR31187; PTHR31187; 1.
DR   Pfam; PF03219; TLC; 1.
DR   TIGRFAMs; TIGR00769; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..512
FT                   /note="ADP,ATP carrier protein 4"
FT                   /id="PRO_0000102583"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   512 AA;  58208 MW;  D09A265DC38936EE CRC64;
     MTINASNIEN SFSKINSHFS KLTDYIWPIK RHEISKFLFI TLLMFCILFI QNLIRALKDS
     IVTTMIGAET ISFLKFWGVM PSAFLITVIY VKLVNRMKAE NIFYLIISIF LTFFALFAYV
     IFPNHEMLHL RPVTVHNLTA SLPNLKWFIL LLSKWSFSLF YIIAELWPNV VFALLFWQFV
     NNITTVEESK RFYPLFGLLS QTGIYLAGHF LENLSNINYY VTNKFALQSS FHTLSIQIIL
     TIVLILGIVS IKTFWLLNHK VLDKKHMALL RFKTKNKSIT IAKSFQMILS SRHIRLIATL
     LICYGIAINL VEGPWKAAAT KIYKTPTEYA AFIGSYLSYT GVFTIFFVLL GSNIVRRMGW
     FTSAVITPSI VFITGILFFA VNNFEGFAGL IIANFILTDP ALVAITIGAI QNVLSKSSKY
     TLFDSTKEMA YVPLEPEIKI SGKAAADVIG TKLGKSGSAF LQSLIFIILP SASYQSISIC
     LMIIFILTCV TWIWATKELN KEYKNSIKFS QK