ID   TLCD_RICTY              Reviewed;         512 AA.
AC   Q83W27;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=ADP,ATP carrier protein 4;
DE   AltName: Full=ADP/ATP translocase 4;
GN   Name=tlcD; Synonyms=tlc4; OrderedLocusNames=RT0486;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=12574860; DOI=10.1007/s00239-002-2387-0;
RA   Amiri H., Karlberg O., Andersson S.G.;
RT   "Deep origin of plastid/parasite ATP/ADP translocases.";
RL   J. Mol. Evol. 56:137-150(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
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DR   EMBL; AJ507310; CAD45263.1; -; Genomic_DNA.
DR   EMBL; AE017197; AAU03958.1; -; Genomic_DNA.
DR   RefSeq; WP_011190940.1; NC_006142.1.
DR   AlphaFoldDB; Q83W27; -.
DR   STRING; 257363.RT0486; -.
DR   EnsemblBacteria; AAU03958; AAU03958; RT0486.
DR   KEGG; rty:RT0486; -.
DR   eggNOG; COG3202; Bacteria.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OMA; FLMTAIY; -.
DR   OrthoDB; 427341at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   PANTHER; PTHR31187; PTHR31187; 1.
DR   Pfam; PF03219; TLC; 1.
DR   TIGRFAMs; TIGR00769; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..512
FT                   /note="ADP,ATP carrier protein 4"
FT                   /id="PRO_0000286477"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        448..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   512 AA;  58333 MW;  2946C5706FC5BFDE CRC64;
     MTINASNIEN SFSKINSHFS KLTDYIWPIK RNEISKFLFI TLLMFCILFI QNLIRALKDS
     IVTTMIGAET ISFLKFWGVM PSAFLITVMY VKLVNRMKAE NIFYLIISIF LIFFALFAYV
     IFPNHEILHL RPVTVHNLTT SLPNLKWFIL LLSKWSFSLF YIIAELWPNV VFALLFWQFV
     NNITTVEESK RFYPLFGLLS QTGIYLAGHF LENLSKINYY ITDKFALQSS FHTLSIQIIL
     TIVLILGIVS IKTFWLLNHK VLDKKHMSLL RFKTKNKSIT IAKSFQMILS SRHIRLIATL
     LICYGIAINL VEGPWKAAAT KIYKTPTEYA AFIGSYLSYT GVFTIFFVLL GSNIVRRIGW
     FTSAVITPSI VFITGILFFA FNNFEGFAGL IIANFILTDP ALVAITIGAI QNVLSKSSKY
     TLFDSTKEMA YVPLEPEIKI SGKAAADVIG TKLGKSGSAF LQSLIFIILP SSSYQSISIC
     LMIIFILTCL TWIWATKELN KEYKNSIKFS QK