ID   TLCE_RICTY              Reviewed;         500 AA.
AC   Q68W11;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=ADP,ATP carrier protein 5;
DE   AltName: Full=ADP/ATP translocase 5;
GN   Name=tlcE; Synonyms=tlc5; OrderedLocusNames=RT0724;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
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DR   EMBL; AE017197; AAU04181.1; -; Genomic_DNA.
DR   RefSeq; WP_011191157.1; NC_006142.1.
DR   AlphaFoldDB; Q68W11; -.
DR   STRING; 257363.RT0724; -.
DR   EnsemblBacteria; AAU04181; AAU04181; RT0724.
DR   KEGG; rty:RT0724; -.
DR   eggNOG; COG3202; Bacteria.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OMA; TSKEMLY; -.
DR   OrthoDB; 427341at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   PANTHER; PTHR31187; PTHR31187; 1.
DR   Pfam; PF03219; TLC; 1.
DR   TIGRFAMs; TIGR00769; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..500
FT                   /note="ADP,ATP carrier protein 5"
FT                   /id="PRO_0000286480"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   500 AA;  57166 MW;  73F44142C89EDCF9 CRC64;
     MLSTSQSRSF KNKFRAAFWP VHNYELGKFI PISALMFCIL FNQNILRILK DSILISEISA
     EIAGFAKVYC VTPVAALFVI IYAKMINHLT FEKIFYYLSA FFISCFILFA FVIYPNIHIF
     HVHPDTLSDW MNKYPHFKWY ISLVGNWGYI VYYSLAELWP NIFYVLLFWQ FTNELTTTEE
     AKRFYTLFSL FGNSSLILVG FLMMNLSSED TIIKKFVSIS DSKITLVQVS TTIVAIVAII
     CCLLVRFISK YIFTNPLFYA KIKKSRSTTQ RMGLIKSFKY IAKSKYLWLL LICSAAFGFA
     INLVEAVWKA KIKELYPTVN TYAEFNSLYI LWTGVAIIVM TIIGNNVMRM HNWFVAAVIS
     PVIIMVTGIL FFVLIVFDQQ ILSLFDGAIL MSPLALAVSI GGIQNILAKG TKYSIWDTSR
     EMLYIPLDDE LKTKGKAAVD VISAKIGKSS SGLVQSIIFT LVPNATFTSI SPILMVVFTF
     VCFAWIYAVR KIYFEYQKIT