ID   TLCOE_ALOMR             Reviewed;          62 AA.
AC   A9XDG5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Omega-lycotoxin-Gsp2671e;
DE            Short=Omega-LCTX-Gsp2671e;
DE   AltName: Full=Omega-Lsp-IA-like 6;
DE   Flags: Precursor; Fragment;
OS   Alopecosa marikovskyi (Wolf spider) (Lycosa kazakhstanicus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Alopecosa.
OX   NCBI_TaxID=2066572;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=17888477; DOI=10.1016/j.toxicon.2007.07.004;
RA   Pluzhnikov K.A., Vassilevski A., Korolkova Y., Fisyunov A., Iegorova O.,
RA   Krishtal O., Grishin E.;
RT   "Omega-Lsp-IA, a novel modulator of P-type Ca(2+) channels.";
RL   Toxicon 50:993-1004(2007).
CC   -!- FUNCTION: Modulates P-type voltage-gated calcium channels
CC       (Cav2.1/CACNA1A) in rat cerebellar Purkinje cells and hippocampal CA1-
CC       CA3 neurons. At saturating concentrations (>10 nM) the toxin
CC       decelerates activation kinetics and slightly increases peak amplitude
CC       without affecting deactivation kinetics (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin (omega-lctx) family.
CC       {ECO:0000305}.
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DR   EMBL; EF187337; ABP68831.1; -; mRNA.
DR   AlphaFoldDB; A9XDG5; -.
DR   SMR; A9XDG5; -.
DR   ArachnoServer; AS000634; omega-lycotoxin-Gsp2671e.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   PROPEP          <1..15
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000388741"
FT   CHAIN           16..62
FT                   /note="Omega-lycotoxin-Gsp2671e"
FT                   /id="PRO_0000388742"
FT   DISULFID        19..34
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..57
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   62 AA;  7283 MW;  24CBEB8D80C91CC8 CRC64;
     EDEVEETLPV AEEGREKSCI TWRNSCVHND KGCCFPWSCV CWSQTVSRNS SRKEKKCQCR
     LW