TLDC2_HUMAN
ID TLDC2_HUMAN Reviewed; 215 AA.
AC A0PJX2; B3KVU8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=TLD domain-containing protein 2;
DE AltName: Full=TBC/LysM-associated domain-containing protein 2;
GN Name=TLDC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
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DR EMBL; AK123544; BAG53910.1; -; mRNA.
DR EMBL; BC127688; AAI27689.1; -; mRNA.
DR EMBL; BC130646; AAI30647.1; -; mRNA.
DR EMBL; BC130648; AAI30649.1; -; mRNA.
DR CCDS; CCDS33465.1; -.
DR RefSeq; NP_001291712.1; NM_001304783.1.
DR RefSeq; NP_542195.1; NM_080628.2.
DR RefSeq; XP_016883161.1; XM_017027672.1.
DR AlphaFoldDB; A0PJX2; -.
DR SMR; A0PJX2; -.
DR BioGRID; 126667; 13.
DR IntAct; A0PJX2; 5.
DR STRING; 9606.ENSP00000217320; -.
DR iPTMnet; A0PJX2; -.
DR PhosphoSitePlus; A0PJX2; -.
DR BioMuta; TLDC2; -.
DR MassIVE; A0PJX2; -.
DR PaxDb; A0PJX2; -.
DR PeptideAtlas; A0PJX2; -.
DR PRIDE; A0PJX2; -.
DR ProteomicsDB; 67; -.
DR Antibodypedia; 62406; 37 antibodies from 10 providers.
DR DNASU; 140711; -.
DR Ensembl; ENST00000217320.8; ENSP00000217320.3; ENSG00000101342.10.
DR Ensembl; ENST00000602922.5; ENSP00000473323.1; ENSG00000101342.10.
DR GeneID; 140711; -.
DR KEGG; hsa:140711; -.
DR MANE-Select; ENST00000217320.8; ENSP00000217320.3; NM_080628.3; NP_542195.1.
DR UCSC; uc002xgg.2; human.
DR CTD; 140711; -.
DR DisGeNET; 140711; -.
DR GeneCards; TLDC2; -.
DR HGNC; HGNC:16112; TLDC2.
DR HPA; ENSG00000101342; Tissue enhanced (intestine).
DR neXtProt; NX_A0PJX2; -.
DR OpenTargets; ENSG00000101342; -.
DR PharmGKB; PA25658; -.
DR VEuPathDB; HostDB:ENSG00000101342; -.
DR eggNOG; KOG2372; Eukaryota.
DR GeneTree; ENSGT00940000161648; -.
DR HOGENOM; CLU_029204_4_1_1; -.
DR InParanoid; A0PJX2; -.
DR OMA; YRGGSHP; -.
DR OrthoDB; 767847at2759; -.
DR PhylomeDB; A0PJX2; -.
DR TreeFam; TF316541; -.
DR PathwayCommons; A0PJX2; -.
DR SignaLink; A0PJX2; -.
DR BioGRID-ORCS; 140711; 20 hits in 1072 CRISPR screens.
DR ChiTaRS; TLDC2; human.
DR GenomeRNAi; 140711; -.
DR Pharos; A0PJX2; Tdark.
DR PRO; PR:A0PJX2; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; A0PJX2; protein.
DR Bgee; ENSG00000101342; Expressed in sural nerve and 90 other tissues.
DR ExpressionAtlas; A0PJX2; baseline and differential.
DR Genevisible; A0PJX2; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR InterPro; IPR006571; TLDc_dom.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00584; TLDc; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..215
FT /note="TLD domain-containing protein 2"
FT /id="PRO_0000318690"
FT DOMAIN 54..215
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..37
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 102
FT /note="G -> R (in dbSNP:rs3748460)"
FT /id="VAR_050439"
SQ SEQUENCE 215 AA; 23912 MW; 6245E8FAC2C16D15 CRC64;
MRGLRWRYTR LPSQVEDTLS GEEGNEEEEE EEAAPDPAAA PEDPTVPQLT EASQVLSASE
IRQLSFHFPP RVTGHPWSLV FCTSRDGFSL QSLYRRMEGC SGPVLLVLRD QDGQIFGAFS
SSAIRLSKGF YGTGETFLFS FSPQLKVFKW TGSNSFFVKG DLDSLMMGSG SGRFGLWLDG
DLFRGGSSPC PTFNNEVLAR QEQFCIQELE AWLLS
