ID   TLDC2_MOUSE             Reviewed;         198 AA.
AC   A2ACG1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=TLD domain-containing protein 2;
DE   AltName: Full=TBC/LysM-associated domain-containing protein 2;
GN   Name=Tldc2; Synonyms=Gm1332;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
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DR   EMBL; AL669828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A2ACG1; -.
DR   SMR; A2ACG1; -.
DR   STRING; 10090.ENSMUSP00000129278; -.
DR   PaxDb; A2ACG1; -.
DR   PRIDE; A2ACG1; -.
DR   Antibodypedia; 62406; 37 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000099140; ENSMUSP00000096743; ENSMUSG00000074628.
DR   MGI; MGI:2686178; Tldc2.
DR   VEuPathDB; HostDB:ENSMUSG00000074628; -.
DR   eggNOG; KOG2372; Eukaryota.
DR   GeneTree; ENSGT00940000161648; -.
DR   HOGENOM; CLU_029204_4_1_1; -.
DR   InParanoid; A2ACG1; -.
DR   OMA; YRGGSHP; -.
DR   PRO; PR:A2ACG1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2ACG1; protein.
DR   Bgee; ENSMUSG00000074628; Expressed in ileum and 22 other tissues.
DR   ExpressionAtlas; A2ACG1; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IDA:MGI.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..198
FT                   /note="TLD domain-containing protein 2"
FT                   /id="PRO_0000318691"
FT   DOMAIN          37..198
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   198 AA;  21987 MW;  78107353E7E4D9DE CRC64;
     MEDTLSGEEG EEEEEEEPAP APAPQDPVEP QLTEASQVLG ASEIKQLSLH LPPRVTGHPW
     SLVFCTSRDG FSLRRLYRQM EGHSGPVLLL LRDQDGQMFG AFSSSAIRLS KGFYGTGETF
     LFSFSPQLKV FKWTGHNSFF VKGDLDSLMM GSGSGQFGLW LDGDLYHGGS YPCATFNNEV
     LARREQFCIK ELEAWVLS