BSPH2_MOUSE
ID BSPH2_MOUSE Reviewed; 131 AA.
AC Q0Q236;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Binder of sperm protein homolog 2 {ECO:0000312|MGI:MGI:1924934};
DE Flags: Precursor;
GN Name=Bsph2 {ECO:0000312|MGI:MGI:1924934};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:ABB71593.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=CD-1 {ECO:0000312|EMBL:ABB71593.1};
RC TISSUE=Epididymis {ECO:0000312|EMBL:ABB71593.1};
RX PubMed=17085770; DOI=10.1093/molehr/gal098;
RA Lefebvre J., Fan J., Chevalier S., Sullivan R., Carmona E., Manjunath P.;
RT "Genomic structure and tissue-specific expression of human and mouse genes
RT encoding homologues of the major bovine seminal plasma proteins.";
RL Mol. Hum. Reprod. 13:45-53(2007).
RN [2] {ECO:0000312|EMBL:ABG65679.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR {ECO:0000312|EMBL:ABG65679.1};
RC TISSUE=Epididymis {ECO:0000312|EMBL:ABG65679.1};
RA Oh J., Cho C.;
RT "Identification and characterization of novel genes expressed in
RT epididymis.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AC120846}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=24307707; DOI=10.1095/biolreprod.113.114272;
RA Plante G., Fan J., Manjunath P.;
RT "Murine Binder of SPerm homolog 2 (BSPH2): the black sheep of the BSP
RT superfamily.";
RL Biol. Reprod. 90:20-20(2014).
CC -!- FUNCTION: Binds sperm in vitro but has no effect on sperm capacitation.
CC Also binds gelatin and heparin, but not chondroitin sulfate B or
CC phospholipid liposomes. {ECO:0000269|PubMed:24307707}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Epididymis. {ECO:0000269|Ref.2}.
CC -!- SIMILARITY: Belongs to the seminal plasma protein family.
CC {ECO:0000305}.
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DR EMBL; DQ227499; ABB71593.1; -; mRNA.
DR EMBL; DQ664198; ABG65679.1; -; mRNA.
DR EMBL; AC120846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52028.1; -.
DR RefSeq; NP_001074411.1; NM_001080942.2.
DR AlphaFoldDB; Q0Q236; -.
DR SMR; Q0Q236; -.
DR STRING; 10090.ENSMUSP00000104166; -.
DR PaxDb; Q0Q236; -.
DR PRIDE; Q0Q236; -.
DR ProteomicsDB; 273775; -.
DR Ensembl; ENSMUST00000108526; ENSMUSP00000104166; ENSMUSG00000078800.
DR GeneID; 77684; -.
DR KEGG; mmu:77684; -.
DR UCSC; uc009ffx.1; mouse.
DR CTD; 77684; -.
DR MGI; MGI:1924934; Bsph2.
DR VEuPathDB; HostDB:ENSMUSG00000078800; -.
DR eggNOG; KOG1565; Eukaryota.
DR GeneTree; ENSGT00940000163805; -.
DR HOGENOM; CLU_126630_1_0_1; -.
DR InParanoid; Q0Q236; -.
DR OMA; YDWCSLD; -.
DR OrthoDB; 1429125at2759; -.
DR PhylomeDB; Q0Q236; -.
DR TreeFam; TF343543; -.
DR BioGRID-ORCS; 77684; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q0Q236; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q0Q236; protein.
DR Bgee; ENSMUSG00000078800; Expressed in yolk sac and 5 other tissues.
DR ExpressionAtlas; Q0Q236; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IDA:MGI.
DR CDD; cd00062; FN2; 1.
DR Gene3D; 2.10.10.10; -; 2.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR Pfam; PF00040; fn2; 2.
DR SMART; SM00059; FN2; 2.
DR SUPFAM; SSF57440; SSF57440; 2.
DR PROSITE; PS51092; FN2_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..131
FT /note="Binder of sperm protein homolog 2"
FT /id="PRO_5004175719"
FT DOMAIN 35..79
FT /note="Fibronectin type-II 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DOMAIN 80..128
FT /note="Fibronectin type-II 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DISULFID 40..64
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DISULFID 54..77
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DISULFID 85..111
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
FT DISULFID 99..126
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 131 AA; 15641 MW; 6DDFC741C17549ED CRC64;
MEVMSHLVHW VFLAVYMYEL NAELISHLHP PEQEISTDSC VFPFVYADGF HYSCISLHSD
YDWCSLDFQF QGRWRYCTAQ DPPKCIFPFQ FKQKLIKKCT KEGYILNRSW CSLTENYNQD
GKWKQCSPNN F
