ID   TLDD_HAEIN              Reviewed;         482 AA.
AC   P45297;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Metalloprotease TldD homolog;
DE            EC=3.4.-.-;
GN   Name=tldD; OrderedLocusNames=HI_1653;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Probable metalloprotease. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase U62 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=L42023; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L42023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; I64173; I64173.
DR   AlphaFoldDB; P45297; -.
DR   SMR; P45297; -.
DR   PhylomeDB; P45297; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; -; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   Pfam; PF01523; PmbA_TldD; 1.
DR   Pfam; PF19289; PmbA_TldD_C; 1.
DR   Pfam; PF19290; PmbA_TldD_M; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; SSF111283; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metalloprotease; Protease; Reference proteome.
FT   CHAIN           1..482
FT                   /note="Metalloprotease TldD homolog"
FT                   /id="PRO_0000142359"
SQ   SEQUENCE   482 AA;  51715 MW;  047DF8680511F680 CRC64;
     MLNQVSNTLL TPSNLSTQTL LNIFDIMSHR NIDYADLYFQ LSQDESWVLE DGIIKEGSFH
     IDRGVGVRAV SGEKTGFAYA DQINLASLQQ CAEAVKGIAQ VKQGNLISPS AFNVVNPIAR
     YAAINPLESL TKEKKIELLH LVDRTARAED HRVTKVSASL SSVYEEVLIM ATDGTLAADI
     RPLVRLSISV LVEENGKRER GSCGSGGRFG LDWFFEVVDG DIRAVLFAKE AVRQALVNLS
     AVAAPAGLMP VVLGAGWPGV LLHEAVGHGL EGDFNRKESS LFTGKIGEQV TSPLCTIVDD
     GTIENRRGSL TIDDEGVPSQ CNVLIKDGIL QGYMQDKMNA RLMGVSTTGN GRRESYAHLP
     MPRMTNTYML AGQSQFDDLI ASVKQGIYAP HFGGGQVDIT SGKFVFSTSE AYLIEKGKIT
     KPVKGATLIG SGIEVMQKIS MVADKSELDL GIGVCGKEGQ SVPVGVGQPA LKIDEITVGG
     TN