ID   TLE1_XENLA              Reviewed;         767 AA.
AC   O42469;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Transducin-like enhancer protein 1;
DE   AltName: Full=Enhancer of split groucho-like protein 1;
DE            Short=ESG1;
GN   Name=esg1; Synonyms=esg;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=9300818; DOI=10.1016/s0378-1119(97)00150-9;
RA   Choudhury B.K., Kim J., Kung H.-F., Li S.S.-L.;
RT   "Cloning and developmental expression of Xenopus cDNAs encoding the
RT   Enhancer of split groucho and related proteins.";
RL   Gene 195:41-48(1997).
CC   -!- FUNCTION: Nuclear effector molecule. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Abundantly expressed in brain, lung, testis and
CC       ovary in comparison with liver, heart, kidney and spleen. Ubiquitously
CC       expressed in the developing embryo. Present in unfertilized and
CC       fertilized eggs.
CC   -!- PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
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DR   EMBL; U18775; AAC60271.1; -; mRNA.
DR   AlphaFoldDB; O42469; -.
DR   SMR; O42469; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10814; PTHR10814; 1.
DR   Pfam; PF03920; TLE_N; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR01850; GROUCHOFAMLY.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ubl conjugation; WD repeat.
FT   CHAIN           1..767
FT                   /note="Transducin-like enhancer protein 1"
FT                   /id="PRO_0000051290"
FT   REPEAT          467..498
FT                   /note="WD 1"
FT   REPEAT          525..555
FT                   /note="WD 2"
FT   REPEAT          569..599
FT                   /note="WD 3"
FT   REPEAT          611..641
FT                   /note="WD 4"
FT   REPEAT          693..723
FT                   /note="WD 5"
FT   REPEAT          734..764
FT                   /note="WD 6"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..274
FT                   /note="CCN domain"
FT   COMPBIAS        232..261
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   767 AA;  82974 MW;  99460BAE6E307D7B CRC64;
     MFPQNRPPTH LQASVATGAA SGPPQSLKLT YPETLDRIKE EFQFLQSQYH SLKLECEKLA
     TEKTEIQRHY VMYYEMSYGL NIEMHKQTEI AKRLNVICAQ LVPFLSQEHQ QQVVQAVERA
     KQVTMAELNA AIGVRFIPPQ LTVHQLQAQH LSHHAPPIPL TPHPSSLQHP GLAAATSASS
     LLGYLVFLAF RHNLLQKRAA DAEHRERDPG PSCLTLPNGE RVPTLSDYLN SNTKRKTEEK
     DFGTDYGSDA DRSEDNLVVD EDPASPHSVH SYSSRENGVD KPTLQRKDPP PASPNSMTSS
     SSVSPSRSKD IPSQQVEKAG TPGLKSSTPN SQSDLNTPGP SGTSASQFRS IATKPAIDSL
     ALGLRTPLGG QGGYPAAFSI AHPSVNADGA GAYAGLHLMS PQINGATAAG TYGRSPLVSY
     DPHAHMRGLG SAIPGSASGK PAYSFHVSAD GQMQPVPFPP DALIGSGIPR HARQLHVLNH
     GEVVCAVTIS NSTRHVYTGG KGCVKVWDVG QPGTKTPVAQ LDCLNRDNYI RSCKLLPDGR
     SLIVGGEAST LSIWDLASPT PRIKAELTSS APACYALAIS PDAKVCFSCC SDGNIVVWDL
     QNQTLVRQFQ GHTDGASCID ISHDGTKLWT GGLDNTVRCW DLREGRQLQQ HDFNSQIFSL
     GYCPTGEWLA VGMESSNIEV LHVSKPDKYQ LHLHESCVLS LQFASCGKWF VSTGKDNLLN
     AWRTPYGASI FQSKESSSVL SCDVSTDDQF IVTGSGDKKA TVYEVIY