位置:首页 > 蛋白库 > TLE3_RAT
TLE3_RAT
ID   TLE3_RAT                Reviewed;         764 AA.
AC   Q9JIT3;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Transducin-like enhancer protein 3;
DE            Short=rTLE3;
GN   Name=Tle3; Synonyms=Esp3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=10800926; DOI=10.1046/j.1471-4159.2000.0741838.x;
RA   Feldman J.D., Vician L., Crispino M., Hoe W., Baudry M., Herschman H.R.;
RT   "rTLE3, a newly identified transducin-like enhancer of split, is induced by
RT   depolarization in brain.";
RL   J. Neurochem. 74:1838-1847(2000).
RN   [2]
RP   REVIEW.
RX   PubMed=18254933; DOI=10.1186/gb-2008-9-1-205;
RA   Jennings B.H., Ish-Horowicz D.;
RT   "The Groucho/TLE/Grg family of transcriptional co-repressors.";
RL   Genome Biol. 9:R205.1-R205.7(2008).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-217; SER-245;
RP   THR-259; SER-263 AND SER-267, AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Transcriptional corepressor that binds to a number of
CC       transcription factors. Inhibits the transcriptional activation mediated
CC       by CTNNB1 and TCF family members in Wnt signaling. The effects of full-
CC       length TLE family members may be modulated by association with
CC       dominant-negative AES (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer and heterooligomer with other family members.
CC       Binds LEF1, TCF7, TCF7L1, TCF7L2 and FOXA2. Interacts with XIAP/BIRC4
CC       and TCF7L2/TCF4. Interacts with TBX18 (via engrailed homology 1
CC       repressor motif), leading to decreased of TBX18 transcriptional
CC       activity. {ECO:0000250|UniProtKB:Q04726, ECO:0000250|UniProtKB:Q08122}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Highly expressed in adrenal gland, small intestine,
CC       kidney, lung, ovary and thyroid. Detected at lower levels in pituitary,
CC       hippocampus, cortex, cerebellum and testis.
CC   -!- INDUCTION: By kainic acid in the dentate gyrus.
CC   -!- DOMAIN: WD repeat Groucho/TLE family members are characterized by 5
CC       regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a
CC       central CcN domain, containing a nuclear localization signal, and a
CC       serine/proline-rich SP domain. The most highly conserved are the N-
CC       terminal Q domain and the C-terminal WD-repeat domain.
CC       {ECO:0000305|PubMed:18254933}.
CC   -!- PTM: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect
CC       its stability, nuclear localization, or capacity to tetramerize but
CC       inhibits its interaction with TCF7L2/TCF4 (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF186092; AAF75590.1; -; mRNA.
DR   RefSeq; NP_445852.1; NM_053400.1.
DR   AlphaFoldDB; Q9JIT3; -.
DR   SMR; Q9JIT3; -.
DR   STRING; 10116.ENSRNOP00000018467; -.
DR   iPTMnet; Q9JIT3; -.
DR   PhosphoSitePlus; Q9JIT3; -.
DR   PaxDb; Q9JIT3; -.
DR   PRIDE; Q9JIT3; -.
DR   GeneID; 84424; -.
DR   KEGG; rno:84424; -.
DR   UCSC; RGD:620292; rat.
DR   CTD; 7090; -.
DR   RGD; 620292; Tle3.
DR   VEuPathDB; HostDB:ENSRNOG00000013013; -.
DR   eggNOG; KOG0639; Eukaryota.
DR   HOGENOM; CLU_007612_3_0_1; -.
DR   InParanoid; Q9JIT3; -.
DR   OMA; FDTQMRQ; -.
DR   OrthoDB; 546143at2759; -.
DR   PhylomeDB; Q9JIT3; -.
DR   Reactome; R-RNO-201722; Formation of the beta-catenin:TCF transactivating complex.
DR   Reactome; R-RNO-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Reactome; R-RNO-4641265; Repression of WNT target genes.
DR   Reactome; R-RNO-9018519; Estrogen-dependent gene expression.
DR   PRO; PR:Q9JIT3; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000013013; Expressed in thymus and 19 other tissues.
DR   Genevisible; Q9JIT3; RN.
DR   GO; GO:1990907; C:beta-catenin-TCF complex; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:RGD.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10814; PTHR10814; 1.
DR   Pfam; PF03920; TLE_N; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR01850; GROUCHOFAMLY.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Ubl conjugation;
KW   WD repeat; Wnt signaling pathway.
FT   CHAIN           1..764
FT                   /note="Transducin-like enhancer protein 3"
FT                   /id="PRO_0000051282"
FT   REPEAT          476..514
FT                   /note="WD 1"
FT   REPEAT          522..561
FT                   /note="WD 2"
FT   REPEAT          566..605
FT                   /note="WD 3"
FT   REPEAT          608..647
FT                   /note="WD 4"
FT   REPEAT          649..688
FT                   /note="WD 5"
FT   REPEAT          690..729
FT                   /note="WD 6"
FT   REPEAT          731..763
FT                   /note="WD 7"
FT   REGION          1..131
FT                   /note="Q domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q04724"
FT   REGION          130..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..199
FT                   /note="GP domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q04724"
FT   REGION          184..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..268
FT                   /note="CcN domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q04724"
FT   REGION          269..444
FT                   /note="SP domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q04724"
FT   MOTIF           225..228
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        141..155
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..301
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         203
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         207
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         211
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         217
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         232
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04727"
FT   MOD_RES         240
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         245
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         259
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         263
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         267
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         275
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04727"
FT   MOD_RES         286
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         312
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         317
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         319
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         321
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         328
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         334
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
FT   MOD_RES         410
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q04726"
SQ   SEQUENCE   764 AA;  82644 MW;  7C5EAAEC9AA1A2DB CRC64;
     MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH
     YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN
     AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLAV
     KDEKNHHELD HRERESSTNN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS
     DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARGLK KDAPTSPASV ASSSSTPSSK
     TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISL
     TSSYAAPFAM MSHHEMNGSL TSPSAYAGLH NIPSQMSAAA AAAAAAYGRS PMVGFDPHPP
     MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR QINTLSHGEV
     VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI
     VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCCSDG NIAVWDLHNQ
     TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC
     PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR
     TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024