TLE5_HUMAN
ID TLE5_HUMAN Reviewed; 197 AA.
AC Q08117; B2RBL0; Q12808; Q14CJ1; Q96TG9; Q9UDY9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2002, sequence version 4.
DT 03-AUG-2022, entry version 197.
DE RecName: Full=TLE family member 5 {ECO:0000305};
DE AltName: Full=Amino-terminal enhancer of split;
DE Short=Amino enhancer of split;
DE AltName: Full=Gp130-associated protein GAM;
DE AltName: Full=Grg-5;
DE AltName: Full=Groucho-related protein 5;
DE AltName: Full=Protein ESP1;
DE AltName: Full=Protein GRG;
DE AltName: Full=TLE family member 5, transcriptional modulator {ECO:0000305};
GN Name=TLE5 {ECO:0000312|HGNC:HGNC:307}; Synonyms=AES, GRG, GRG5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Neuroblastoma;
RA Scala L.A., Piparo K.E., Tirumalai P.S., Howells R.D.;
RT "Molecular cloning, sequence analysis and characterization of a human
RT homolog of Drosophila enhancer of split m9/m10.";
RL Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Lymphocyte, and Umbilical cord;
RX PubMed=9809752; DOI=10.1089/dna.1998.17.911;
RA Hou E.W., Li S.S.-L.;
RT "Genomic organization and chromosome localization to band 19p13.3 of the
RT human AES gene: gene product exhibits strong similarity to the N-terminal
RT domain of Drosophila enhancer of split Groucho protein.";
RL DNA Cell Biol. 17:911-913(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RA Liu Y., Jin B.Q., Liu F.;
RT "Cloning and eukaryotic expressing of a novel gp130 associated molecule.";
RL Zhonghua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi 18:106-110(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 13-197 (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=8365415; DOI=10.1111/j.1432-1033.1993.tb18151.x;
RA Miyasaka H., Choudhury B.K., Hou E.W., Li S.S.-L.;
RT "Molecular cloning and expression of mouse and human cDNA encoding AES and
RT ESG proteins with strong similarity to Drosophila enhancer of split groucho
RT protein.";
RL Eur. J. Biochem. 216:343-352(1993).
RN [9]
RP FUNCTION, AND INTERACTION WITH RELA.
RX PubMed=10660609; DOI=10.1074/jbc.275.6.4383;
RA Tetsuka T., Uranishi H., Imai H., Ono T., Sonta S., Takahashi N.,
RA Asamitsu K., Okamoto T.;
RT "Inhibition of nuclear factor-kappaB-mediated transcription by association
RT with the amino-terminal enhancer of split, a Groucho-related protein
RT lacking WD40 repeats.";
RL J. Biol. Chem. 275:4383-4390(2000).
RN [10]
RP FUNCTION, AND OLIGOMERIZATION.
RX PubMed=10748198; DOI=10.1074/jbc.m910211199;
RA Wang J.-C., Waltner-Law M., Yamada K., Osawa H., Stifani S., Granner D.K.;
RT "Transducin-like enhancer of split proteins, the human homologs of
RT Drosophila groucho, interact with hepatic nuclear factor 3beta.";
RL J. Biol. Chem. 275:18418-18423(2000).
RN [11]
RP INTERACTION WITH PHF12.
RX PubMed=11390640; DOI=10.1128/mcb.21.13.4110-4118.2001;
RA Yochum G.S., Ayer D.E.;
RT "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the
RT mSin3A-histone deacetylase complex.";
RL Mol. Cell. Biol. 21:4110-4118(2001).
RN [12]
RP INTERACTION WITH SIX3.
RX PubMed=12441302; DOI=10.1242/dev.00185;
RA Lopez-Rios J., Tessmar K., Loosli F., Wittbrodt J., Bovolenta P.;
RT "Six3 and Six6 activity is modulated by members of the groucho family.";
RL Development 130:185-195(2003).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [14]
RP UBIQUITINATION BY XIAP/BIRC4.
RX PubMed=22304967; DOI=10.1016/j.molcel.2011.12.032;
RA Hanson A.J., Wallace H.A., Freeman T.J., Beauchamp R.D., Lee L.A., Lee E.;
RT "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.";
RL Mol. Cell 45:619-628(2012).
CC -!- FUNCTION: Transcriptional corepressor. Acts as dominant repressor
CC towards other family members. Inhibits NF-kappa-B-regulated gene
CC expression. May be required for the initiation and maintenance of the
CC differentiated state. Essential for the transcriptional repressor
CC activity of SIX3 during retina and lens development.
CC {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}.
CC -!- SUBUNIT: Homooligomer and heterooligomer with other family members.
CC Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA.
CC Interacts with PHF12. Interacts (via Q domain) with SIX3. Interacts
CC with SIX6. {ECO:0000250, ECO:0000269|PubMed:10660609,
CC ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:12441302}.
CC -!- INTERACTION:
CC Q08117; Q9NYB9: ABI2; NbExp=5; IntAct=EBI-717810, EBI-743598;
CC Q08117; Q8WTP8: AEN; NbExp=3; IntAct=EBI-717810, EBI-8637627;
CC Q08117; A7KAX9: ARHGAP32; NbExp=3; IntAct=EBI-717810, EBI-308663;
CC Q08117; P54253: ATXN1; NbExp=3; IntAct=EBI-717810, EBI-930964;
CC Q08117; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-717810, EBI-742750;
CC Q08117; P41182: BCL6; NbExp=3; IntAct=EBI-717810, EBI-765407;
CC Q08117; O14503: BHLHE40; NbExp=3; IntAct=EBI-717810, EBI-711810;
CC Q08117; Q96CA5: BIRC7; NbExp=4; IntAct=EBI-717810, EBI-517623;
CC Q08117; Q13895: BYSL; NbExp=5; IntAct=EBI-717810, EBI-358049;
CC Q08117; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-717810, EBI-8643161;
CC Q08117; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-717810, EBI-747505;
CC Q08117; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-717810, EBI-946029;
CC Q08117; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-717810, EBI-739580;
CC Q08117; Q9H257: CARD9; NbExp=4; IntAct=EBI-717810, EBI-751319;
CC Q08117; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-717810, EBI-2808286;
CC Q08117; F6RF56: CCNJL; NbExp=3; IntAct=EBI-717810, EBI-10177725;
CC Q08117; O75909: CCNK; NbExp=3; IntAct=EBI-717810, EBI-739806;
CC Q08117; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-717810, EBI-749051;
CC Q08117; Q96Q77: CIB3; NbExp=3; IntAct=EBI-717810, EBI-10292696;
CC Q08117; Q8N684: CPSF7; NbExp=3; IntAct=EBI-717810, EBI-746909;
CC Q08117; Q9BSW2: CRACR2A; NbExp=4; IntAct=EBI-717810, EBI-739773;
CC Q08117; O43186: CRX; NbExp=3; IntAct=EBI-717810, EBI-748171;
CC Q08117; P26196: DDX6; NbExp=3; IntAct=EBI-717810, EBI-351257;
CC Q08117; Q14689-6: DIP2A; NbExp=3; IntAct=EBI-717810, EBI-10233719;
CC Q08117; Q96JC9: EAF1; NbExp=4; IntAct=EBI-717810, EBI-769261;
CC Q08117; O60573: EIF4E2; NbExp=3; IntAct=EBI-717810, EBI-398610;
CC Q08117; Q86V42: FAM124A; NbExp=3; IntAct=EBI-717810, EBI-744506;
CC Q08117; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-717810, EBI-741626;
CC Q08117; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-717810, EBI-10244131;
CC Q08117; O15409: FOXP2; NbExp=3; IntAct=EBI-717810, EBI-983612;
CC Q08117; O43559: FRS3; NbExp=3; IntAct=EBI-717810, EBI-725515;
CC Q08117; A1L4K1: FSD2; NbExp=4; IntAct=EBI-717810, EBI-5661036;
CC Q08117; P14136: GFAP; NbExp=3; IntAct=EBI-717810, EBI-744302;
CC Q08117; Q08379: GOLGA2; NbExp=3; IntAct=EBI-717810, EBI-618309;
CC Q08117; Q9H8Y8: GORASP2; NbExp=4; IntAct=EBI-717810, EBI-739467;
CC Q08117; P62993: GRB2; NbExp=3; IntAct=EBI-717810, EBI-401755;
CC Q08117; P52597: HNRNPF; NbExp=3; IntAct=EBI-717810, EBI-352986;
CC Q08117; Q8IX15-3: HOMEZ; NbExp=3; IntAct=EBI-717810, EBI-10172004;
CC Q08117; P42858: HTT; NbExp=3; IntAct=EBI-717810, EBI-466029;
CC Q08117; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-717810, EBI-747204;
CC Q08117; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-717810, EBI-2556193;
CC Q08117; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-717810, EBI-2125614;
CC Q08117; A1A4E9: KRT13; NbExp=3; IntAct=EBI-717810, EBI-10171552;
CC Q08117; P19012: KRT15; NbExp=3; IntAct=EBI-717810, EBI-739566;
CC Q08117; Q15323: KRT31; NbExp=3; IntAct=EBI-717810, EBI-948001;
CC Q08117; Q6A162: KRT40; NbExp=3; IntAct=EBI-717810, EBI-10171697;
CC Q08117; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-717810, EBI-10172290;
CC Q08117; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-717810, EBI-10171774;
CC Q08117; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-717810, EBI-10172052;
CC Q08117; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-717810, EBI-739909;
CC Q08117; O95751: LDOC1; NbExp=3; IntAct=EBI-717810, EBI-740738;
CC Q08117; Q96FQ7: LINC00526; NbExp=3; IntAct=EBI-717810, EBI-10286106;
CC Q08117; P25800: LMO1; NbExp=3; IntAct=EBI-717810, EBI-8639312;
CC Q08117; P25791: LMO2; NbExp=3; IntAct=EBI-717810, EBI-739696;
CC Q08117; P61968: LMO4; NbExp=3; IntAct=EBI-717810, EBI-2798728;
CC Q08117; Q9Y333: LSM2; NbExp=3; IntAct=EBI-717810, EBI-347416;
CC Q08117; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-717810, EBI-746778;
CC Q08117; Q86VM6: MBNL1; NbExp=3; IntAct=EBI-717810, EBI-10225084;
CC Q08117; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-717810, EBI-394607;
CC Q08117; P55081: MFAP1; NbExp=3; IntAct=EBI-717810, EBI-1048159;
CC Q08117; Q96PC5: MIA2; NbExp=3; IntAct=EBI-717810, EBI-1050253;
CC Q08117; Q9UH92: MLX; NbExp=4; IntAct=EBI-717810, EBI-741109;
CC Q08117; Q15014: MORF4L2; NbExp=3; IntAct=EBI-717810, EBI-399257;
CC Q08117; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-717810, EBI-742948;
CC Q08117; Q15742: NAB2; NbExp=3; IntAct=EBI-717810, EBI-8641936;
CC Q08117; Q9UBB6: NCDN; NbExp=3; IntAct=EBI-717810, EBI-1053490;
CC Q08117; Q9HC98: NEK6; NbExp=3; IntAct=EBI-717810, EBI-740364;
CC Q08117; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-717810, EBI-945833;
CC Q08117; Q9BRQ3: NUDT22; NbExp=4; IntAct=EBI-717810, EBI-10297093;
CC Q08117; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-717810, EBI-10225049;
CC Q08117; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-717810, EBI-9057006;
CC Q08117; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-717810, EBI-3921217;
CC Q08117; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-717810, EBI-710402;
CC Q08117; Q13131: PRKAA1; NbExp=3; IntAct=EBI-717810, EBI-1181405;
CC Q08117; P54646: PRKAA2; NbExp=3; IntAct=EBI-717810, EBI-1383852;
CC Q08117; O75360: PROP1; NbExp=4; IntAct=EBI-717810, EBI-9027467;
CC Q08117; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-717810, EBI-1567797;
CC Q08117; P79522: PRR3; NbExp=3; IntAct=EBI-717810, EBI-2803328;
CC Q08117; Q9Y3E5: PTRH2; NbExp=7; IntAct=EBI-717810, EBI-1056751;
CC Q08117; P47897: QARS1; NbExp=3; IntAct=EBI-717810, EBI-347462;
CC Q08117; P47897-2: QARS1; NbExp=3; IntAct=EBI-717810, EBI-10209725;
CC Q08117; P98175: RBM10; NbExp=3; IntAct=EBI-717810, EBI-721525;
CC Q08117; Q93062: RBPMS; NbExp=3; IntAct=EBI-717810, EBI-740322;
CC Q08117; Q04864: REL; NbExp=3; IntAct=EBI-717810, EBI-307352;
CC Q08117; Q8HWS3: RFX6; NbExp=3; IntAct=EBI-717810, EBI-746118;
CC Q08117; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-717810, EBI-372094;
CC Q08117; Q9UFD9: RIMBP3; NbExp=3; IntAct=EBI-717810, EBI-10182375;
CC Q08117; Q96EP0-3: RNF31; NbExp=3; IntAct=EBI-717810, EBI-10225152;
CC Q08117; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-717810, EBI-748391;
CC Q08117; O00560: SDCBP; NbExp=3; IntAct=EBI-717810, EBI-727004;
CC Q08117; Q15475: SIX1; NbExp=3; IntAct=EBI-717810, EBI-743675;
CC Q08117; P12757: SKIL; NbExp=3; IntAct=EBI-717810, EBI-2902468;
CC Q08117; P84022: SMAD3; NbExp=4; IntAct=EBI-717810, EBI-347161;
CC Q08117; Q5TAL4: SNRPC; NbExp=3; IntAct=EBI-717810, EBI-10246938;
CC Q08117; P35711: SOX5; NbExp=4; IntAct=EBI-717810, EBI-3505701;
CC Q08117; P78362: SRPK2; NbExp=3; IntAct=EBI-717810, EBI-593303;
CC Q08117; O75716: STK16; NbExp=3; IntAct=EBI-717810, EBI-749295;
CC Q08117; O75558: STX11; NbExp=3; IntAct=EBI-717810, EBI-714135;
CC Q08117; O15119: TBX3; NbExp=3; IntAct=EBI-717810, EBI-3452216;
CC Q08117; P15884: TCF4; NbExp=3; IntAct=EBI-717810, EBI-533224;
CC Q08117; Q13077: TRAF1; NbExp=3; IntAct=EBI-717810, EBI-359224;
CC Q08117; Q12933: TRAF2; NbExp=3; IntAct=EBI-717810, EBI-355744;
CC Q08117; Q12899: TRIM26; NbExp=3; IntAct=EBI-717810, EBI-2341136;
CC Q08117; P14373: TRIM27; NbExp=4; IntAct=EBI-717810, EBI-719493;
CC Q08117; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-717810, EBI-725997;
CC Q08117; Q8IV54: TSC22D4; NbExp=3; IntAct=EBI-717810, EBI-10261521;
CC Q08117; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-717810, EBI-744794;
CC Q08117; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-717810, EBI-3918381;
CC Q08117; P26368: U2AF2; NbExp=3; IntAct=EBI-717810, EBI-742339;
CC Q08117; Q5T124: UBXN11; NbExp=3; IntAct=EBI-717810, EBI-746004;
CC Q08117; Q9H9H4: VPS37B; NbExp=3; IntAct=EBI-717810, EBI-4400866;
CC Q08117; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-717810, EBI-2559305;
CC Q08117; O43167: ZBTB24; NbExp=3; IntAct=EBI-717810, EBI-744471;
CC Q08117; Q8N5A5: ZGPAT; NbExp=4; IntAct=EBI-717810, EBI-3439227;
CC Q08117; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-717810, EBI-10183064;
CC Q08117; Q9H609: ZNF576; NbExp=3; IntAct=EBI-717810, EBI-3921014;
CC Q08117; Q9H614; NbExp=3; IntAct=EBI-717810, EBI-10249899;
CC Q08117-2; Q9NYB9-2: ABI2; NbExp=6; IntAct=EBI-11741437, EBI-11096309;
CC Q08117-2; O95994: AGR2; NbExp=3; IntAct=EBI-11741437, EBI-712648;
CC Q08117-2; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-11741437, EBI-357530;
CC Q08117-2; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-11741437, EBI-12224467;
CC Q08117-2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-11741437, EBI-17183751;
CC Q08117-2; Q9Y575-3: ASB3; NbExp=3; IntAct=EBI-11741437, EBI-14199987;
CC Q08117-2; O95429: BAG4; NbExp=3; IntAct=EBI-11741437, EBI-2949658;
CC Q08117-2; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-11741437, EBI-742750;
CC Q08117-2; O14503: BHLHE40; NbExp=3; IntAct=EBI-11741437, EBI-711810;
CC Q08117-2; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-11741437, EBI-517623;
CC Q08117-2; Q9NP55: BPIFA1; NbExp=5; IntAct=EBI-11741437, EBI-953896;
CC Q08117-2; Q13895: BYSL; NbExp=5; IntAct=EBI-11741437, EBI-358049;
CC Q08117-2; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-11741437, EBI-12809220;
CC Q08117-2; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-11741437, EBI-718615;
CC Q08117-2; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-11741437, EBI-725606;
CC Q08117-2; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-11741437, EBI-11976299;
CC Q08117-2; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-11741437, EBI-8643161;
CC Q08117-2; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-11741437, EBI-946029;
CC Q08117-2; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-11741437, EBI-739879;
CC Q08117-2; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-11741437, EBI-12011224;
CC Q08117-2; Q9NP86: CABP5; NbExp=5; IntAct=EBI-11741437, EBI-10311131;
CC Q08117-2; Q96HB5: CCDC120; NbExp=6; IntAct=EBI-11741437, EBI-744556;
CC Q08117-2; O75909-2: CCNK; NbExp=3; IntAct=EBI-11741437, EBI-12010594;
CC Q08117-2; P22674: CCNO; NbExp=3; IntAct=EBI-11741437, EBI-2556878;
CC Q08117-2; Q96Q77: CIB3; NbExp=3; IntAct=EBI-11741437, EBI-10292696;
CC Q08117-2; O95833: CLIC3; NbExp=3; IntAct=EBI-11741437, EBI-10192241;
CC Q08117-2; Q96DZ5: CLIP3; NbExp=3; IntAct=EBI-11741437, EBI-12823145;
CC Q08117-2; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-11741437, EBI-12819063;
CC Q08117-2; Q96BR5: COA7; NbExp=3; IntAct=EBI-11741437, EBI-6269632;
CC Q08117-2; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-11741437, EBI-11523759;
CC Q08117-2; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-11741437, EBI-739773;
CC Q08117-2; O43186: CRX; NbExp=3; IntAct=EBI-11741437, EBI-748171;
CC Q08117-2; P68400: CSNK2A1; NbExp=3; IntAct=EBI-11741437, EBI-347804;
CC Q08117-2; P33240: CSTF2; NbExp=3; IntAct=EBI-11741437, EBI-711360;
CC Q08117-2; Q9H0L4: CSTF2T; NbExp=6; IntAct=EBI-11741437, EBI-747012;
CC Q08117-2; Q8WUE5: CT55; NbExp=3; IntAct=EBI-11741437, EBI-6873363;
CC Q08117-2; P56545-3: CTBP2; NbExp=3; IntAct=EBI-11741437, EBI-10171902;
CC Q08117-2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11741437, EBI-3867333;
CC Q08117-2; Q15038: DAZAP2; NbExp=3; IntAct=EBI-11741437, EBI-724310;
CC Q08117-2; P26196: DDX6; NbExp=3; IntAct=EBI-11741437, EBI-351257;
CC Q08117-2; Q9Y5R5: DMRT2; NbExp=3; IntAct=EBI-11741437, EBI-18072054;
CC Q08117-2; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11741437, EBI-9679045;
CC Q08117-2; Q96MA1: DMRTB1; NbExp=3; IntAct=EBI-11741437, EBI-954466;
CC Q08117-2; Q6PKX4: DOK6; NbExp=3; IntAct=EBI-11741437, EBI-2880244;
CC Q08117-2; O14641: DVL2; NbExp=3; IntAct=EBI-11741437, EBI-740850;
CC Q08117-2; Q92997: DVL3; NbExp=3; IntAct=EBI-11741437, EBI-739789;
CC Q08117-2; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-11741437, EBI-740680;
CC Q08117-2; O95967: EFEMP2; NbExp=6; IntAct=EBI-11741437, EBI-743414;
CC Q08117-2; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-11741437, EBI-743105;
CC Q08117-2; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-11741437, EBI-750700;
CC Q08117-2; P50548: ERF; NbExp=3; IntAct=EBI-11741437, EBI-8465203;
CC Q08117-2; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-11741437, EBI-371876;
CC Q08117-2; O00167-2: EYA2; NbExp=3; IntAct=EBI-11741437, EBI-12807776;
CC Q08117-2; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-11741437, EBI-11986315;
CC Q08117-2; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-11741437, EBI-12193763;
CC Q08117-2; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-11741437, EBI-745689;
CC Q08117-2; Q9NTX9: FAM217B; NbExp=3; IntAct=EBI-11741437, EBI-19153639;
CC Q08117-2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-11741437, EBI-6658203;
CC Q08117-2; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-11741437, EBI-11958845;
CC Q08117-2; Q13643: FHL3; NbExp=4; IntAct=EBI-11741437, EBI-741101;
CC Q08117-2; P53539: FOSB; NbExp=3; IntAct=EBI-11741437, EBI-2806743;
CC Q08117-2; O60548: FOXD2; NbExp=3; IntAct=EBI-11741437, EBI-17282008;
CC Q08117-2; O15353: FOXN1; NbExp=3; IntAct=EBI-11741437, EBI-11319000;
CC Q08117-2; O15409: FOXP2; NbExp=3; IntAct=EBI-11741437, EBI-983612;
CC Q08117-2; O43559: FRS3; NbExp=5; IntAct=EBI-11741437, EBI-725515;
CC Q08117-2; A1L4K1: FSD2; NbExp=3; IntAct=EBI-11741437, EBI-5661036;
CC Q08117-2; P15976-2: GATA1; NbExp=5; IntAct=EBI-11741437, EBI-9090198;
CC Q08117-2; Q96CN9: GCC1; NbExp=3; IntAct=EBI-11741437, EBI-746252;
CC Q08117-2; P55040: GEM; NbExp=3; IntAct=EBI-11741437, EBI-744104;
CC Q08117-2; O75420: GIGYF1; NbExp=3; IntAct=EBI-11741437, EBI-947774;
CC Q08117-2; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-11741437, EBI-7251368;
CC Q08117-2; Q08379: GOLGA2; NbExp=6; IntAct=EBI-11741437, EBI-618309;
CC Q08117-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11741437, EBI-5916454;
CC Q08117-2; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-11741437, EBI-739467;
CC Q08117-2; O95872: GPANK1; NbExp=3; IntAct=EBI-11741437, EBI-751540;
CC Q08117-2; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-11741437, EBI-11959863;
CC Q08117-2; P28799: GRN; NbExp=3; IntAct=EBI-11741437, EBI-747754;
CC Q08117-2; P13807: GYS1; NbExp=5; IntAct=EBI-11741437, EBI-740553;
CC Q08117-2; P56524-2: HDAC4; NbExp=3; IntAct=EBI-11741437, EBI-11953488;
CC Q08117-2; Q9BSH5: HDHD3; NbExp=3; IntAct=EBI-11741437, EBI-745201;
CC Q08117-2; A0A087WSW0: HELT; NbExp=4; IntAct=EBI-11741437, EBI-12057631;
CC Q08117-2; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-11741437, EBI-5460660;
CC Q08117-2; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-11741437, EBI-16429135;
CC Q08117-2; O14964: HGS; NbExp=8; IntAct=EBI-11741437, EBI-740220;
CC Q08117-2; Q03014: HHEX; NbExp=3; IntAct=EBI-11741437, EBI-747421;
CC Q08117-2; P52597: HNRNPF; NbExp=3; IntAct=EBI-11741437, EBI-352986;
CC Q08117-2; P61978-2: HNRNPK; NbExp=5; IntAct=EBI-11741437, EBI-7060731;
CC Q08117-2; P49639: HOXA1; NbExp=3; IntAct=EBI-11741437, EBI-740785;
CC Q08117-2; P09067: HOXB5; NbExp=5; IntAct=EBI-11741437, EBI-3893317;
CC Q08117-2; P31273: HOXC8; NbExp=3; IntAct=EBI-11741437, EBI-1752118;
CC Q08117-2; P31274: HOXC9; NbExp=3; IntAct=EBI-11741437, EBI-1779423;
CC Q08117-2; Q9UKT9: IKZF3; NbExp=5; IntAct=EBI-11741437, EBI-747204;
CC Q08117-2; Q9C086: INO80B; NbExp=5; IntAct=EBI-11741437, EBI-715611;
CC Q08117-2; Q8NBZ0: INO80E; NbExp=3; IntAct=EBI-11741437, EBI-769401;
CC Q08117-2; Q15735: INPP5J; NbExp=3; IntAct=EBI-11741437, EBI-10236940;
CC Q08117-2; Q9BZI1: IRX2; NbExp=3; IntAct=EBI-11741437, EBI-12166369;
CC Q08117-2; P78412: IRX6; NbExp=5; IntAct=EBI-11741437, EBI-12100506;
CC Q08117-2; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-11741437, EBI-2556193;
CC Q08117-2; O60341: KDM1A; NbExp=3; IntAct=EBI-11741437, EBI-710124;
CC Q08117-2; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-11741437, EBI-14069005;
CC Q08117-2; Q13351: KLF1; NbExp=3; IntAct=EBI-11741437, EBI-8284732;
CC Q08117-2; O43474: KLF4; NbExp=3; IntAct=EBI-11741437, EBI-7232405;
CC Q08117-2; Q96G42: KLHDC7B; NbExp=3; IntAct=EBI-11741437, EBI-9478422;
CC Q08117-2; O76011: KRT34; NbExp=3; IntAct=EBI-11741437, EBI-1047093;
CC Q08117-2; Q92764: KRT35; NbExp=3; IntAct=EBI-11741437, EBI-1058674;
CC Q08117-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-11741437, EBI-10171697;
CC Q08117-2; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-11741437, EBI-10217483;
CC Q08117-2; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11741437, EBI-10172290;
CC Q08117-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11741437, EBI-10171774;
CC Q08117-2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11741437, EBI-1052037;
CC Q08117-2; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11741437, EBI-10176379;
CC Q08117-2; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11741437, EBI-11953846;
CC Q08117-2; Q3SY46: KRTAP13-3; NbExp=5; IntAct=EBI-11741437, EBI-10241252;
CC Q08117-2; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11741437, EBI-11988175;
CC Q08117-2; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-11741437, EBI-1048945;
CC Q08117-2; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-11741437, EBI-10241353;
CC Q08117-2; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11741437, EBI-11962084;
CC Q08117-2; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-11741437, EBI-18394498;
CC Q08117-2; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-11741437, EBI-10261141;
CC Q08117-2; P01130: LDLR; NbExp=3; IntAct=EBI-11741437, EBI-988319;
CC Q08117-2; O95751: LDOC1; NbExp=3; IntAct=EBI-11741437, EBI-740738;
CC Q08117-2; Q96PV6: LENG8; NbExp=3; IntAct=EBI-11741437, EBI-739546;
CC Q08117-2; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-11741437, EBI-12039345;
CC Q08117-2; P25791-3: LMO2; NbExp=3; IntAct=EBI-11741437, EBI-11959475;
CC Q08117-2; P61968: LMO4; NbExp=3; IntAct=EBI-11741437, EBI-2798728;
CC Q08117-2; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-11741437, EBI-741037;
CC Q08117-2; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-11741437, EBI-746778;
CC Q08117-2; P28482: MAPK1; NbExp=3; IntAct=EBI-11741437, EBI-959949;
CC Q08117-2; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-11741437, EBI-726739;
CC Q08117-2; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-11741437, EBI-348259;
CC Q08117-2; Q99750: MDFI; NbExp=3; IntAct=EBI-11741437, EBI-724076;
CC Q08117-2; Q86YW9: MED12L; NbExp=3; IntAct=EBI-11741437, EBI-3957138;
CC Q08117-2; Q71SY5: MED25; NbExp=3; IntAct=EBI-11741437, EBI-394558;
CC Q08117-2; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-11741437, EBI-18582591;
CC Q08117-2; P55081: MFAP1; NbExp=5; IntAct=EBI-11741437, EBI-1048159;
CC Q08117-2; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-11741437, EBI-2801965;
CC Q08117-2; Q13064: MKRN3; NbExp=5; IntAct=EBI-11741437, EBI-2340269;
CC Q08117-2; P40692: MLH1; NbExp=3; IntAct=EBI-11741437, EBI-744248;
CC Q08117-2; P55198: MLLT6; NbExp=3; IntAct=EBI-11741437, EBI-740216;
CC Q08117-2; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-11741437, EBI-8852072;
CC Q08117-2; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-11741437, EBI-10288852;
CC Q08117-2; Q4VC12: MSS51; NbExp=3; IntAct=EBI-11741437, EBI-11599933;
CC Q08117-2; P35548: MSX2; NbExp=3; IntAct=EBI-11741437, EBI-6447480;
CC Q08117-2; Q5JR59-3: MTUS2; NbExp=6; IntAct=EBI-11741437, EBI-11522433;
CC Q08117-2; P13349: MYF5; NbExp=3; IntAct=EBI-11741437, EBI-17491620;
CC Q08117-2; A7E2Y1-2: MYH7B; NbExp=3; IntAct=EBI-11741437, EBI-12813813;
CC Q08117-2; P15173: MYOG; NbExp=3; IntAct=EBI-11741437, EBI-3906629;
CC Q08117-2; Q15742: NAB2; NbExp=3; IntAct=EBI-11741437, EBI-8641936;
CC Q08117-2; Q96HR8: NAF1; NbExp=5; IntAct=EBI-11741437, EBI-2515597;
CC Q08117-2; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-11741437, EBI-10249760;
CC Q08117-2; P17568: NDUFB7; NbExp=3; IntAct=EBI-11741437, EBI-1246238;
CC Q08117-2; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-11741437, EBI-11750983;
CC Q08117-2; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11741437, EBI-22310682;
CC Q08117-2; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-11741437, EBI-741158;
CC Q08117-2; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-11741437, EBI-10297093;
CC Q08117-2; P61970: NUTF2; NbExp=3; IntAct=EBI-11741437, EBI-591778;
CC Q08117-2; Q7RTU3: OLIG3; NbExp=5; IntAct=EBI-11741437, EBI-10225049;
CC Q08117-2; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-11741437, EBI-9057006;
CC Q08117-2; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-11741437, EBI-12813389;
CC Q08117-2; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-11741437, EBI-10181968;
CC Q08117-2; Q9HBI0: PARVG; NbExp=5; IntAct=EBI-11741437, EBI-3921217;
CC Q08117-2; Q9HBE1-4: PATZ1; NbExp=5; IntAct=EBI-11741437, EBI-11022007;
CC Q08117-2; Q06710: PAX8; NbExp=3; IntAct=EBI-11741437, EBI-2683132;
CC Q08117-2; P55771: PAX9; NbExp=3; IntAct=EBI-11741437, EBI-12111000;
CC Q08117-2; Q15365: PCBP1; NbExp=3; IntAct=EBI-11741437, EBI-946095;
CC Q08117-2; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11741437, EBI-11956269;
CC Q08117-2; Q99471: PFDN5; NbExp=3; IntAct=EBI-11741437, EBI-357275;
CC Q08117-2; O43189: PHF1; NbExp=3; IntAct=EBI-11741437, EBI-530034;
CC Q08117-2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-11741437, EBI-79165;
CC Q08117-2; P78337: PITX1; NbExp=8; IntAct=EBI-11741437, EBI-748265;
CC Q08117-2; Q99697-2: PITX2; NbExp=3; IntAct=EBI-11741437, EBI-12138495;
CC Q08117-2; Q9UM63: PLAGL1; NbExp=3; IntAct=EBI-11741437, EBI-7233410;
CC Q08117-2; O15160: POLR1C; NbExp=3; IntAct=EBI-11741437, EBI-1055079;
CC Q08117-2; Q9GZV8: PRDM14; NbExp=5; IntAct=EBI-11741437, EBI-3957793;
CC Q08117-2; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-11741437, EBI-11320284;
CC Q08117-2; P54646: PRKAA2; NbExp=3; IntAct=EBI-11741437, EBI-1383852;
CC Q08117-2; O43741: PRKAB2; NbExp=5; IntAct=EBI-11741437, EBI-1053424;
CC Q08117-2; O75360: PROP1; NbExp=3; IntAct=EBI-11741437, EBI-9027467;
CC Q08117-2; Q8WWY3: PRPF31; NbExp=10; IntAct=EBI-11741437, EBI-1567797;
CC Q08117-2; P79522: PRR3; NbExp=3; IntAct=EBI-11741437, EBI-2803328;
CC Q08117-2; P0CG20: PRR35; NbExp=5; IntAct=EBI-11741437, EBI-11986293;
CC Q08117-2; P20618: PSMB1; NbExp=3; IntAct=EBI-11741437, EBI-372273;
CC Q08117-2; P28070: PSMB4; NbExp=5; IntAct=EBI-11741437, EBI-603350;
CC Q08117-2; O75771: RAD51D; NbExp=3; IntAct=EBI-11741437, EBI-1055693;
CC Q08117-2; Q93062-3: RBPMS; NbExp=5; IntAct=EBI-11741437, EBI-740343;
CC Q08117-2; Q8N443: RIBC1; NbExp=3; IntAct=EBI-11741437, EBI-10265323;
CC Q08117-2; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-11741437, EBI-10226430;
CC Q08117-2; Q92753-1: RORB; NbExp=3; IntAct=EBI-11741437, EBI-18560266;
CC Q08117-2; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-11741437, EBI-6257312;
CC Q08117-2; P21673: SAT1; NbExp=3; IntAct=EBI-11741437, EBI-711613;
CC Q08117-2; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-11741437, EBI-748391;
CC Q08117-2; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-11741437, EBI-748621;
CC Q08117-2; Q01105-2: SET; NbExp=3; IntAct=EBI-11741437, EBI-7481343;
CC Q08117-2; Q15427: SF3B4; NbExp=3; IntAct=EBI-11741437, EBI-348469;
CC Q08117-2; O14492-2: SH2B2; NbExp=3; IntAct=EBI-11741437, EBI-19952306;
CC Q08117-2; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11741437, EBI-11955083;
CC Q08117-2; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-11741437, EBI-12037847;
CC Q08117-2; Q15475: SIX1; NbExp=6; IntAct=EBI-11741437, EBI-743675;
CC Q08117-2; Q9NPC8: SIX2; NbExp=3; IntAct=EBI-11741437, EBI-12695166;
CC Q08117-2; P84022: SMAD3; NbExp=3; IntAct=EBI-11741437, EBI-347161;
CC Q08117-2; Q13485: SMAD4; NbExp=3; IntAct=EBI-11741437, EBI-347263;
CC Q08117-2; Q12824-2: SMARCB1; NbExp=3; IntAct=EBI-11741437, EBI-358436;
CC Q08117-2; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-11741437, EBI-358489;
CC Q08117-2; P09012: SNRPA; NbExp=3; IntAct=EBI-11741437, EBI-607085;
CC Q08117-2; P09234: SNRPC; NbExp=3; IntAct=EBI-11741437, EBI-766589;
CC Q08117-2; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-11741437, EBI-12288855;
CC Q08117-2; P35711-4: SOX5; NbExp=3; IntAct=EBI-11741437, EBI-11954419;
CC Q08117-2; Q9BR10: SPATA25; NbExp=3; IntAct=EBI-11741437, EBI-12926726;
CC Q08117-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-11741437, EBI-742688;
CC Q08117-2; O75558: STX11; NbExp=3; IntAct=EBI-11741437, EBI-714135;
CC Q08117-2; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-11741437, EBI-740595;
CC Q08117-2; O95947: TBX6; NbExp=3; IntAct=EBI-11741437, EBI-2824328;
CC Q08117-2; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11741437, EBI-11955057;
CC Q08117-2; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-11741437, EBI-11746252;
CC Q08117-2; Q15561: TEAD4; NbExp=3; IntAct=EBI-11741437, EBI-747736;
CC Q08117-2; Q96A09: TENT5B; NbExp=6; IntAct=EBI-11741437, EBI-752030;
CC Q08117-2; Q96LM6: TEX37; NbExp=3; IntAct=EBI-11741437, EBI-743976;
CC Q08117-2; Q7Z6R9: TFAP2D; NbExp=5; IntAct=EBI-11741437, EBI-11952651;
CC Q08117-2; Q9BT49: THAP7; NbExp=3; IntAct=EBI-11741437, EBI-741350;
CC Q08117-2; Q6B0B8: TIGD3; NbExp=3; IntAct=EBI-11741437, EBI-12140557;
CC Q08117-2; Q08117-2: TLE5; NbExp=5; IntAct=EBI-11741437, EBI-11741437;
CC Q08117-2; Q13077: TRAF1; NbExp=6; IntAct=EBI-11741437, EBI-359224;
CC Q08117-2; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-11741437, EBI-492476;
CC Q08117-2; Q12899: TRIM26; NbExp=3; IntAct=EBI-11741437, EBI-2341136;
CC Q08117-2; Q8WV44: TRIM41; NbExp=5; IntAct=EBI-11741437, EBI-725997;
CC Q08117-2; Q15654: TRIP6; NbExp=3; IntAct=EBI-11741437, EBI-742327;
CC Q08117-2; Q8IZ69: TRMT2A; NbExp=3; IntAct=EBI-11741437, EBI-2515774;
CC Q08117-2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-11741437, EBI-12806590;
CC Q08117-2; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-11741437, EBI-372432;
CC Q08117-2; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11741437, EBI-10241197;
CC Q08117-2; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-11741437, EBI-9090990;
CC Q08117-2; P26368-2: U2AF2; NbExp=3; IntAct=EBI-11741437, EBI-11097439;
CC Q08117-2; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-11741437, EBI-2514383;
CC Q08117-2; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-11741437, EBI-607755;
CC Q08117-2; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-11741437, EBI-11524408;
CC Q08117-2; O75604: USP2; NbExp=5; IntAct=EBI-11741437, EBI-743272;
CC Q08117-2; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-11741437, EBI-11975223;
CC Q08117-2; Q14119: VEZF1; NbExp=3; IntAct=EBI-11741437, EBI-11980193;
CC Q08117-2; Q99990: VGLL1; NbExp=3; IntAct=EBI-11741437, EBI-11983165;
CC Q08117-2; P08670: VIM; NbExp=3; IntAct=EBI-11741437, EBI-353844;
CC Q08117-2; Q9H9H4: VPS37B; NbExp=3; IntAct=EBI-11741437, EBI-4400866;
CC Q08117-2; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-11741437, EBI-2559305;
CC Q08117-2; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-11741437, EBI-1051237;
CC Q08117-2; Q05516: ZBTB16; NbExp=3; IntAct=EBI-11741437, EBI-711925;
CC Q08117-2; O43167: ZBTB24; NbExp=3; IntAct=EBI-11741437, EBI-744471;
CC Q08117-2; Q9UFB7: ZBTB47; NbExp=5; IntAct=EBI-11741437, EBI-7781767;
CC Q08117-2; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-11741437, EBI-10237226;
CC Q08117-2; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-11741437, EBI-16428984;
CC Q08117-2; Q8N5A5-2: ZGPAT; NbExp=9; IntAct=EBI-11741437, EBI-10183064;
CC Q08117-2; Q15915: ZIC1; NbExp=3; IntAct=EBI-11741437, EBI-11963196;
CC Q08117-2; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-11741437, EBI-12030590;
CC Q08117-2; Q9Y3S2: ZNF330; NbExp=5; IntAct=EBI-11741437, EBI-373456;
CC Q08117-2; Q8NA42: ZNF383; NbExp=3; IntAct=EBI-11741437, EBI-20110775;
CC Q08117-2; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11741437, EBI-347633;
CC Q08117-2; Q96IQ9: ZNF414; NbExp=5; IntAct=EBI-11741437, EBI-744257;
CC Q08117-2; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11741437, EBI-740727;
CC Q08117-2; Q7Z7K2: ZNF467; NbExp=3; IntAct=EBI-11741437, EBI-11986485;
CC Q08117-2; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-11741437, EBI-12006434;
CC Q08117-2; Q96F45: ZNF503; NbExp=3; IntAct=EBI-11741437, EBI-8832437;
CC Q08117-2; Q96C55: ZNF524; NbExp=3; IntAct=EBI-11741437, EBI-10283126;
CC Q08117-2; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-11741437, EBI-4395732;
CC Q08117-2; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11741437, EBI-10240849;
CC Q08117-2; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11741437, EBI-5667516;
CC Q08117-2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11741437, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=AES-1;
CC IsoId=Q08117-1; Sequence=Displayed;
CC Name=2; Synonyms=AES-2;
CC IsoId=Q08117-2; Sequence=VSP_043527;
CC -!- TISSUE SPECIFICITY: Found predominantly in muscle, heart and Placenta.
CC In fetal tissues, abundantly expressed in the heart, lung, kidney,
CC brain and liver.
CC -!- DOMAIN: Lacks the C-terminal WD repeats.
CC -!- PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC35517.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U04241; AAA16223.1; -; mRNA.
DR EMBL; U88832; AAD00654.1; -; Genomic_DNA.
DR EMBL; U88831; AAD00654.1; JOINED; Genomic_DNA.
DR EMBL; AF072902; AAC35517.1; ALT_INIT; mRNA.
DR EMBL; AK094591; BAG52894.1; -; mRNA.
DR EMBL; AK314713; BAG37257.1; -; mRNA.
DR EMBL; AC005944; AAC72103.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69345.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69347.1; -; Genomic_DNA.
DR EMBL; BC113735; AAI13736.1; -; mRNA.
DR EMBL; BC113737; AAI13738.1; -; mRNA.
DR EMBL; X73358; CAA51768.1; -; mRNA.
DR CCDS; CCDS12101.1; -. [Q08117-2]
DR CCDS; CCDS12102.1; -. [Q08117-1]
DR PIR; G01236; G01236.
DR PIR; S35678; S35678.
DR PIR; S35679; S35679.
DR RefSeq; NP_001121.2; NM_001130.5. [Q08117-1]
DR RefSeq; NP_945320.1; NM_198969.1. [Q08117-2]
DR RefSeq; NP_945321.1; NM_198970.1.
DR AlphaFoldDB; Q08117; -.
DR SMR; Q08117; -.
DR BioGRID; 106675; 432.
DR IntAct; Q08117; 430.
DR MINT; Q08117; -.
DR STRING; 9606.ENSP00000221561; -.
DR MoonDB; Q08117; Predicted.
DR GlyGen; Q08117; 7 sites, 2 O-linked glycans (7 sites).
DR iPTMnet; Q08117; -.
DR PhosphoSitePlus; Q08117; -.
DR BioMuta; AES; -.
DR DMDM; 23503062; -.
DR EPD; Q08117; -.
DR jPOST; Q08117; -.
DR MassIVE; Q08117; -.
DR MaxQB; Q08117; -.
DR PaxDb; Q08117; -.
DR PeptideAtlas; Q08117; -.
DR PRIDE; Q08117; -.
DR ProteomicsDB; 58572; -. [Q08117-1]
DR ProteomicsDB; 58573; -. [Q08117-2]
DR Antibodypedia; 10920; 399 antibodies from 36 providers.
DR DNASU; 166; -.
DR Ensembl; ENST00000221561.12; ENSP00000221561.7; ENSG00000104964.15. [Q08117-2]
DR Ensembl; ENST00000327141.9; ENSP00000317537.4; ENSG00000104964.15. [Q08117-1]
DR GeneID; 166; -.
DR KEGG; hsa:166; -.
DR MANE-Select; ENST00000327141.9; ENSP00000317537.4; NM_001130.6; NP_001121.2.
DR UCSC; uc002lwy.2; human. [Q08117-1]
DR CTD; 166; -.
DR DisGeNET; 166; -.
DR GeneCards; TLE5; -.
DR HGNC; HGNC:307; TLE5.
DR HPA; ENSG00000104964; Low tissue specificity.
DR MIM; 600188; gene.
DR neXtProt; NX_Q08117; -.
DR OpenTargets; ENSG00000104964; -.
DR PharmGKB; PA24606; -.
DR VEuPathDB; HostDB:ENSG00000104964; -.
DR eggNOG; KOG0639; Eukaryota.
DR GeneTree; ENSGT01030000234519; -.
DR HOGENOM; CLU_092092_0_0_1; -.
DR InParanoid; Q08117; -.
DR OMA; GDTHQDD; -.
DR PhylomeDB; Q08117; -.
DR PathwayCommons; Q08117; -.
DR Reactome; R-HSA-4641265; Repression of WNT target genes.
DR SignaLink; Q08117; -.
DR SIGNOR; Q08117; -.
DR BioGRID-ORCS; 166; 9 hits in 1086 CRISPR screens.
DR ChiTaRS; AES; human.
DR GenomeRNAi; 166; -.
DR Pharos; Q08117; Tbio.
DR PRO; PR:Q08117; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q08117; protein.
DR Bgee; ENSG00000104964; Expressed in right hemisphere of cerebellum and 197 other tissues.
DR ExpressionAtlas; Q08117; baseline and differential.
DR Genevisible; Q08117; HS.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
DR GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
DR GO; GO:0060761; P:negative regulation of response to cytokine stimulus; IMP:BHF-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:2000210; P:positive regulation of anoikis; IMP:UniProtKB.
DR GO; GO:0040008; P:regulation of growth; IEA:Ensembl.
DR GO; GO:0070555; P:response to interleukin-1; IDA:BHF-UCL.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR PANTHER; PTHR10814; PTHR10814; 1.
DR Pfam; PF03920; TLE_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW Repressor; Transcription; Transcription regulation; Ubl conjugation;
KW Wnt signaling pathway.
FT CHAIN 1..197
FT /note="TLE family member 5"
FT /id="PRO_0000050834"
FT REGION 166..197
FT /note="CCN domain"
FT REGION 174..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 196
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VAR_SEQ 1..9
FT /note="MMFPQSRHS -> MCHKNGFPQEGGITAAFLQKRKLRLSKNHRPARAKVTEH
FT VRGTRPGRATAGPAASTRAAGSLFFDRWGNRGPAGCR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8365415"
FT /id="VSP_043527"
FT VARIANT 168
FT /note="A -> E (in dbSNP:rs1802578)"
FT /id="VAR_011958"
FT CONFLICT 30
FT /note="K -> T (in Ref. 2 and 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 197 AA; 21970 MW; 3851663AA6921A9F CRC64;
MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH
YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN
SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK
NGHDGDTHQE DDGEKSD
