TLE5_RAT
ID TLE5_RAT Reviewed; 197 AA.
AC P63003; Q06195; Q3MIF3;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=TLE family member 5;
DE AltName: Full=Amino-terminal enhancer of split;
DE Short=Amino enhancer of split;
DE AltName: Full=Grg-5;
DE AltName: Full=Groucho-related protein 5;
DE AltName: Full=Protein ESP1;
DE Short=R-esp1;
DE AltName: Full=Protein GRG;
GN Name=Tle5; Synonyms=Aes {ECO:0000312|RGD:2731}, Esp1, Grg, Grg5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hippocampus;
RX PubMed=8245004; DOI=10.1016/s0021-9258(19)74443-3;
RA Schmidt C.J., Sladek T.E.;
RT "A rat homolog of the Drosophila enhancer of split (groucho) locus lacking
RT WD-40 repeats.";
RL J. Biol. Chem. 268:25681-25686(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Transcriptional corepressor. Acts as dominant repressor
CC towards other family members. Inhibits NF-kappa-B-regulated gene
CC expression. May be required for the initiation and maintenance of the
CC differentiated state. Essential for the transcriptional repressor
CC activity of SIX3 during retina and lens development (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer and heterooligomer with other family members.
CC Binds TCF7 and the NF-kappa-B subunit RELA. Interacts with PHF12.
CC Interacts (via Q domain) with SIX3. Interacts with SIX6 (By
CC similarity). {ECO:0000250|UniProtKB:P63002,
CC ECO:0000250|UniProtKB:Q08117}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: Lacks the C-terminal WD repeats.
CC -!- PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
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DR EMBL; L14462; AAC37639.1; -; mRNA.
DR EMBL; BC101855; AAI01856.1; -; mRNA.
DR PIR; A49555; A49555.
DR RefSeq; NP_062093.1; NM_019220.1.
DR AlphaFoldDB; P63003; -.
DR SMR; P63003; -.
DR BioGRID; 248109; 1.
DR STRING; 10116.ENSRNOP00000059140; -.
DR iPTMnet; P63003; -.
DR PhosphoSitePlus; P63003; -.
DR jPOST; P63003; -.
DR PaxDb; P63003; -.
DR PRIDE; P63003; -.
DR Ensembl; ENSRNOT00000113477; ENSRNOP00000092723; ENSRNOG00000052025.
DR GeneID; 29466; -.
DR KEGG; rno:29466; -.
DR UCSC; RGD:2731; rat.
DR CTD; 166; -.
DR RGD; 2731; Tle5.
DR eggNOG; KOG0639; Eukaryota.
DR GeneTree; ENSGT01030000234519; -.
DR InParanoid; P63003; -.
DR OrthoDB; 1409798at2759; -.
DR PhylomeDB; P63003; -.
DR PRO; PR:P63003; -.
DR Proteomes; UP000002494; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; ISO:RGD.
DR GO; GO:0031668; P:cellular response to extracellular stimulus; ISO:RGD.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:0032091; P:negative regulation of protein binding; ISO:RGD.
DR GO; GO:0060761; P:negative regulation of response to cytokine stimulus; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:2000210; P:positive regulation of anoikis; ISO:RGD.
DR GO; GO:0040008; P:regulation of growth; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0070555; P:response to interleukin-1; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR PANTHER; PTHR10814; PTHR10814; 1.
DR Pfam; PF03920; TLE_N; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Ubl conjugation; Wnt signaling pathway.
FT CHAIN 1..197
FT /note="TLE family member 5"
FT /id="PRO_0000050836"
FT REGION 166..197
FT /note="CCN domain"
FT REGION 170..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 196
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 197 AA; 22000 MW; 2C00233AA6921A9F CRC64;
MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH
YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN
SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQTHLSKEDK
NGHDGDTHQE DDGEKSD
