TLE7_HUMAN
ID TLE7_HUMAN Reviewed; 441 AA.
AC A0A1W2PR48;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2017, sequence version 1.
DT 03-AUG-2022, entry version 27.
DE RecName: Full=Transducin-like enhancer protein 7 {ECO:0000305};
GN Name=TLE7 {ECO:0000312|HGNC:HGNC:53648};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
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DR EMBL; AC010547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1W2PR48; -.
DR SMR; A0A1W2PR48; -.
DR BioMuta; ENSG00000260734; -.
DR MassIVE; A0A1W2PR48; -.
DR PeptideAtlas; A0A1W2PR48; -.
DR Ensembl; ENST00000561754.4; ENSP00000492311.2; ENSG00000260734.6.
DR MANE-Select; ENST00000561754.4; ENSP00000492311.2; NM_001367365.2; NP_001354294.1.
DR GeneCards; TLE7; -.
DR HGNC; HGNC:53648; TLE7.
DR HPA; ENSG00000260734; Not detected.
DR neXtProt; NX_A0A1W2PR48; -.
DR VEuPathDB; HostDB:ENSG00000260734; -.
DR GeneTree; ENSGT01030000234519; -.
DR OMA; IAGNKFW; -.
DR Pharos; A0A1W2PR48; Tdark.
DR PRO; PR:A0A1W2PR48; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A0A1W2PR48; protein.
DR Bgee; ENSG00000260734; Expressed in testis and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10814; PTHR10814; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..441
FT /note="Transducin-like enhancer protein 7"
FT /id="PRO_0000443311"
FT REPEAT 156..194
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 204..243
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 247..285
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 286..325
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 409..441
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 48656 MW; E177C44839604CB4 CRC64;
MSGEKEEASL RMFGAYGEPE ERRDVLESSG VSSQPEPQVQ QQLGSLLGVP WQPPGPPIQH
SPADQETSTV TQQQWHLQGL GRSELQAAGL PDAQPGEAAE SSPSFLLGSE VGQPYSSSSP
SEEVLSLLRA IPPIPDEVVV RQKRAPQGSW KVGTLFHGKR VYAVAISGST HHVYTCGSGY
IRVWDESALH AGEKAPRAQL DLQHPQDRVV TCKLFPDERS LITGGASQAV TLWDLAPTPQ
VRAQLTSTGP TCYSLAVSSD AHICLACFHG FVEIWDLQNQ ILIRKHEVPV YGSRCVDITG
NIFWTGGEDT ILYSWDLRSY QRLHQHNLQN EILSITHDPG EEWVLAGLRT SDIVFLHTRR
NEQFKALMKK YTRHHSLKFA SCGSYFVTAI DTRLSGLEAP SLQKLFQIEE SSGILCCDVS
SDNQYLVMGS SSSATIYQLL Y
