ID   TLLP_PHONI              Reviewed;         225 AA.
AC   P85031;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Techylectin-like protein;
DE   Flags: Fragments;
OS   Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Phoneutria.
OX   NCBI_TaxID=6918;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom {ECO:0000269|Ref.1};
RA   Richardson M., Resende F.F., Souza I.A., Goncalves J.M., Borges M.H.,
RA   Cordeiro M.N.;
RT   "Techylectin-like protein from venom of spider Phoneutria nigriventer has
RT   sequence similarities to fibrinogen and ficolins.";
RL   Submitted (OCT-2006) to UniProtKB.
CC   -!- FUNCTION: Lectin involved in innate immunity.
CC       {ECO:0000250|UniProtKB:Q9U8W8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
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DR   AlphaFoldDB; P85031; -.
DR   SMR; P85031; -.
DR   ArachnoServer; AS000012; Techylectin-1-Phoneutria nigriventer.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; -; 1.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR020837; Fibrinogen_CS.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Disulfide bond; Lectin; Metal-binding;
KW   Secreted.
FT   CHAIN           1..>225
FT                   /note="Techylectin-like protein"
FT                   /id="PRO_0000260047"
FT   DOMAIN          32..225
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   MOTIF           75..77
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   BINDING         164
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8"
FT   BINDING         170
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8"
FT   SITE            176
FT                   /note="Implicated in ligand binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8"
FT   SITE            186
FT                   /note="Implicated in ligand binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8"
FT   SITE            198
FT                   /note="Implicated in ligand binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8"
FT   SITE            199
FT                   /note="Implicated in ligand binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8"
FT   SITE            210
FT                   /note="Implicated in ligand binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8"
FT   DISULFID        41..60
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8,
FT                   ECO:0000255|PROSITE-ProRule:PRU00739"
FT   DISULFID        172..185
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8W8,
FT                   ECO:0000255|PROSITE-ProRule:PRU00739"
FT   NON_CONS        47..48
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        117..118
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        196..197
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         225
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   225 AA;  25783 MW;  F23E841D0E520434 CRC64;
     LSTTCEGKDK GICNLNLALQ LITDVRDNFP VCPSPPLPID CEEVLQRDFK AIPNPIDVYC
     DMVTDGGGWT VIQRRGDFHG PIDYFYKDWQ SYKKGFGDIE KEFWLGNENI FGLSNQRYAL
     YDTFANDDED HKYMLHISGY KGDAGDSMIG VHNEQKFSTK DKNDNFPGAT SCAQLYKGGW
     WYNQCHVSNL NGQYLKSYAD GVIWRSWKGY HESLGWTEIK IKDVK