TLL_DROVI
ID TLL_DROVI Reviewed; 450 AA.
AC O16845; B4LW79;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein tailless;
DE AltName: Full=Nuclear receptor subfamily 2 group E member 2;
GN Name=tll; Synonyms=NR2E2;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9334278; DOI=10.1242/dev.124.21.4297;
RA Rudolph K.M., Liaw G.-J., Daniel A., Green P., Courey A.J., Hartenstein V.,
RA Lengyel J.A.;
RT "Complex regulatory region mediating tailless expression in early embryonic
RT patterning and brain development.";
RL Development 124:4297-4308(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Orphan receptor that binds DNA as a monomer to hormone
CC response elements (HRE) containing an extended core motif half-site
CC sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate
CC in determining receptor specificity. This receptor binds to the
CC consensus sequence [AG][AG]AAGTCAA. Plays a key role in the
CC establishment of non-metameric domains at the anterior and posterior
CC poles of the embryo. It may also play a role in the nervous system. The
CC maternal terminal pathway activates the tll gene in the termini; TLL
CC activity then represses segmentation and activates terminal-specific
CC genes in these domains. Involved in the regulation of early eye
CC development. In the embryonic visual system anlage drives cells to
CC optic lobe as opposed to Bolwig's organ fate (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000305}.
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DR EMBL; AF019361; AAB71370.1; -; Genomic_DNA.
DR EMBL; CH940650; EDW67613.1; -; Genomic_DNA.
DR PIR; B47265; B47265.
DR RefSeq; XP_002054093.1; XM_002054057.2.
DR AlphaFoldDB; O16845; -.
DR SMR; O16845; -.
DR STRING; 7244.FBpp0238663; -.
DR EnsemblMetazoa; FBtr0240171; FBpp0238663; FBgn0013145.
DR GeneID; 6629478; -.
DR KEGG; dvi:6629478; -.
DR eggNOG; KOG3575; Eukaryota.
DR OMA; VVSLMHK; -.
DR OrthoDB; 870262at2759; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0001222; F:transcription corepressor binding; IEA:EnsemblMetazoa.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045165; P:cell fate commitment; IEA:EnsemblMetazoa.
DR GO; GO:0001748; P:insect visual primordium development; IEA:EnsemblMetazoa.
DR GO; GO:0002121; P:inter-male aggressive behavior; IEA:EnsemblMetazoa.
DR GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0014019; P:neuroblast development; IEA:EnsemblMetazoa.
DR GO; GO:0055057; P:neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:EnsemblMetazoa.
DR GO; GO:0035271; P:ring gland development; IEA:EnsemblMetazoa.
DR GO; GO:0023061; P:signal release; IEA:EnsemblMetazoa.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Receptor; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..450
FT /note="Protein tailless"
FT /id="PRO_0000053598"
FT DOMAIN 187..448
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 31..108
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 34..54
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 70..96
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT CONFLICT 313..317
FT /note="DVLNQ -> AVPNR (in Ref. 1; AAB71370)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 450 AA; 50355 MW; A0CF10D01AB5DB10 CRC64;
MQSSEGSPDM MDQKYNSVRL SPAASSRILY HVPCKVCRDH SSGKHYGIYA CDGCAGFFKR
SIRRSRQYVC KSQKQGLCVV DKTHRNQCRA CRLRKCFEVG MNKDAVQHER GPRNSTLRRH
MAMYKDAMMG AAEMPQIPPE ILMNTAALTG FPGLPMPMPG VQRSHHHAAL SAAFQPPPSA
AVLDLSVPRV PHHPVHQGHH GFFSPTAAYM NALATRALPP TPPLMAAEHI KETAAEHLFK
NVNWIKSVRA FTELPMPDQL LLLEESWKEF FILAMAQYLM PMNFAQLLFV YESENANREI
VTIVAREVHA FQDVLNQLCH LNIDSTEYEC LRAISLFRKS PPAASSTEDL ANSSILTGSG
SPNSSASAES RGLLESSKVA AMHNDARNAL HNYISRTHPN QPLRFQTLLG VVTLMHKVSS
FTIEELFFRK TIGDITIVRL ISDMYSQRKI
