ID   TLP12_ORYSJ             Reviewed;         451 AA.
AC   Q69U54; B9FYN0;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Tubby-like F-box protein 12;
DE            Short=OsTLP12;
DE   AltName: Full=Tubby-like F-box protein 2;
DE            Short=OsTLP2;
GN   Name=TULP12; Synonyms=TULP2;
GN   OrderedLocusNames=Os08g0103300, LOC_Os08g01290;
GN   ORFNames=OsJ_25735 {ECO:0000312|EMBL:EEE67897.1}, P0015C07.29;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18070109; DOI=10.1111/j.1742-4658.2007.06186.x;
RA   Liu Q.;
RT   "Identification of rice TUBBY-like genes and their evolution.";
RL   FEBS J. 275:163-171(2008).
RN   [7]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18620041; DOI=10.1016/j.ygeno.2008.06.001;
RA   Yang Z., Zhou Y., Wang X., Gu S., Yu J., Liang G., Yan C., Xu C.;
RT   "Genomewide comparative phylogenetic and molecular evolutionary analysis of
RT   tubby-like protein family in Arabidopsis, rice, and poplar.";
RL   Genomics 92:246-253(2008).
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:18620041}.
CC   -!- SIMILARITY: Belongs to the TUB family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP004654; BAD33172.1; -; Genomic_DNA.
DR   EMBL; AP008214; BAF22685.1; -; Genomic_DNA.
DR   EMBL; AP014964; BAT03421.1; -; Genomic_DNA.
DR   EMBL; CM000145; EEE67897.1; -; Genomic_DNA.
DR   EMBL; AK120706; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015650083.1; XM_015794597.1.
DR   RefSeq; XP_015650084.1; XM_015794598.1.
DR   RefSeq; XP_015650085.1; XM_015794599.1.
DR   RefSeq; XP_015650086.1; XM_015794600.1.
DR   AlphaFoldDB; Q69U54; -.
DR   SMR; Q69U54; -.
DR   STRING; 4530.OS08T0103300-01; -.
DR   PaxDb; Q69U54; -.
DR   PRIDE; Q69U54; -.
DR   EnsemblPlants; Os08t0103300-01; Os08t0103300-01; Os08g0103300.
DR   GeneID; 4344429; -.
DR   Gramene; Os08t0103300-01; Os08t0103300-01; Os08g0103300.
DR   KEGG; osa:4344429; -.
DR   eggNOG; KOG2502; Eukaryota.
DR   InParanoid; Q69U54; -.
DR   OMA; CQHGSRR; -.
DR   OrthoDB; 1445357at2759; -.
DR   Proteomes; UP000000763; Chromosome 8.
DR   Proteomes; UP000007752; Chromosome 8.
DR   Proteomes; UP000059680; Chromosome 8.
DR   ExpressionAtlas; Q69U54; baseline and differential.
DR   Genevisible; Q69U54; OS.
DR   Gene3D; 3.20.90.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR025659; Tubby-like_C.
DR   InterPro; IPR000007; Tubby_C.
DR   InterPro; IPR018066; Tubby_C_CS.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF01167; Tub; 1.
DR   PRINTS; PR01573; SUPERTUBBY.
DR   SUPFAM; SSF54518; SSF54518; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS01200; TUB_1; 1.
DR   PROSITE; PS01201; TUB_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..451
FT                   /note="Tubby-like F-box protein 12"
FT                   /id="PRO_0000351131"
FT   DOMAIN          57..112
FT                   /note="F-box"
FT   REGION          387..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        411
FT                   /note="V -> M (in Ref. 5; AK120706)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   451 AA;  50528 MW;  F875D1FB652E881E CRC64;
     MSFRSIVRDV RDSFGSLSRR SFEVRISGLP GLSGHHRGKS LGSLSELRDR PVVVDQSRWV
     GLPPELLRDV MKRLEEGESN WPSRKDVVAC AAVCRTWREI CKDIVQSPEI CGKLTFPVSL
     KQPGPRDGLI QCFIKRDKSK LTYYLYLCLS PAVLSENGKF LLAAKRNRRA TSTEYIISVD
     SKNISRSSNG YVGKMRSNFL GTKFVVYDTQ PPYNAGSLMS CQHGSRRISS RRVSPKLPTG
     SYPIAHVKYE LNVLGTRGPR RMQCTMHSIP ASAVDPEGVV PGQPEQLLPG PFEESFRSTN
     TSSRFSFMDR SLDFSSSRFS EISGSANQQG EDDIPEAKER PLVLRNKVPR WHEQLQCWCL
     NFRGRVTVAS VKNFQLIAAA SSESSQLEQQ QQQQQQNHAS SSSSASDHGK VILQFGKVGK
     DMFTMDYRYP LSAFQAFAIC LTSFDTKLAC E