ID   BSRH_BACSU              Reviewed;          29 AA.
AC   A0A2K4Z9K4;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 1.
DT   03-AUG-2022, entry version 13.
DE   RecName: Full=Probable small toxic protein BsrH {ECO:0000303|PubMed:20525796};
GN   Name=bsrH {ECO:0000303|PubMed:18948176}; ORFNames=BSU_26055;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   IDENTIFICATION, AND INDUCTION.
RC   STRAIN=168;
RX   PubMed=18948176; DOI=10.1016/j.gene.2008.09.024;
RA   Saito S., Kakeshita H., Nakamura K.;
RT   "Novel small RNA-encoding genes in the intergenic regions of Bacillus
RT   subtilis.";
RL   Gene 428:2-8(2009).
RN   [3]
RP   IDENTIFICATION, AND DISCUSSION OF POSSIBLE FUNCTION.
RC   STRAIN=168;
RX   PubMed=20525796; DOI=10.1093/nar/gkq454;
RA   Irnov I., Sharma C.M., Vogel J., Winkler W.C.;
RT   "Identification of regulatory RNAs in Bacillus subtilis.";
RL   Nucleic Acids Res. 38:6637-6651(2010).
CC   -!- FUNCTION: Possible toxic component of a type I toxin-antitoxin (TA)
CC       system; an overlapping antisense RNA has been identified.
CC       {ECO:0000303|PubMed:18948176, ECO:0000303|PubMed:20525796}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Accumulates by 2 hours post-innoculation and into stationary
CC       phase in rich media. {ECO:0000269|PubMed:18948176}.
CC   -!- MISCELLANEOUS: Encoded in the skin prophage. {ECO:0000305}.
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DR   EMBL; AL009126; SOX90576.1; -; Genomic_DNA.
DR   RefSeq; WP_075058862.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; A0A2K4Z9K4; -.
DR   SMR; A0A2K4Z9K4; -.
DR   EnsemblBacteria; SOX90576; SOX90576; BSU_26055.
DR   BioCyc; BSUB:BSU_26055-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031616; BsrE-like.
DR   Pfam; PF16935; Hol_Tox; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Toxin-antitoxin system;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..29
FT                   /note="Probable small toxic protein BsrH"
FT                   /id="PRO_0000450221"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   29 AA;  3317 MW;  333DB825A6F8DA1B CRC64;
     MHVSTFQALM LMLAFGSFII ALLTYIKKK