TLP1_CAEEL
ID TLP1_CAEEL Reviewed; 354 AA.
AC G5EGF8;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Zinc finger protein tlp-1 {ECO:0000312|EMBL:AAL02420.1, ECO:0000312|WormBase:T23G4.1};
DE AltName: Full=T cell lineage defective and leptoderan tail protein {ECO:0000303|PubMed:11880358};
GN Name=tlp-1 {ECO:0000312|WormBase:T23G4.1};
GN ORFNames=T23G4.1 {ECO:0000312|WormBase:T23G4.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND MUTAGENESIS OF 77-GLN--GLN-354.
RX PubMed=11880358; DOI=10.1242/dev.129.6.1497;
RA Zhao X., Yang Y., Fitch D.H.A., Herman M.A.;
RT "TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals
RT and controls male tail tip morphogenesis in C. elegans.";
RL Development 129:1497-1508(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=28716930; DOI=10.1073/pnas.1704194114;
RA Li Y., Zhao D., Horie T., Chen G., Bao H., Chen S., Liu W., Horie R.,
RA Liang T., Dong B., Feng Q., Tao Q., Liu X.;
RT "Conserved gene regulatory module specifies lateral neural borders across
RT bilaterians.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:6352-6360(2017).
CC -!- FUNCTION: Probable transcription factor that regulates development of
CC the tail phasmid sensory organs (PubMed:11880358). Involved in
CC migration and differentiation of lateral neuroblasts (PubMed:28716930).
CC Involved in control of cell fate in the T cell lineage
CC (PubMed:11880358). {ECO:0000269|PubMed:11880358,
CC ECO:0000269|PubMed:28716930}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11880358}.
CC -!- DEVELOPMENTAL STAGE: First expressed at the beginning of gastrulation
CC at about 100 minutes; reduces in the anterior of the embryo at about
CC 260 minutes, but persists and increases in the posterior embryo
CC (PubMed:11880358). Expressed in comma-stage embryo in P neuroblasts and
CC the mother cells of V5 and Q neuroblasts (PubMed:28716930). During
CC larval development, expressed in the tail tip cells in hermaphrodites
CC and males, and asymmetrically in descendants of the T cell lineage
CC (PubMed:11880358). {ECO:0000269|PubMed:11880358,
CC ECO:0000269|PubMed:28716930}.
CC -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
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DR EMBL; AY046083; AAL02420.1; -; mRNA.
DR EMBL; BX284604; CAB05282.1; -; Genomic_DNA.
DR PIR; T25198; T25198.
DR RefSeq; NP_502647.1; NM_070246.4.
DR AlphaFoldDB; G5EGF8; -.
DR IntAct; G5EGF8; 3.
DR STRING; 6239.T23G4.1; -.
DR EPD; G5EGF8; -.
DR PaxDb; G5EGF8; -.
DR EnsemblMetazoa; T23G4.1.1; T23G4.1.1; WBGene00006580.
DR GeneID; 178338; -.
DR KEGG; cel:CELE_T23G4.1; -.
DR CTD; 178338; -.
DR WormBase; T23G4.1; CE16453; WBGene00006580; tlp-1.
DR eggNOG; ENOG502TG3K; Eukaryota.
DR GeneTree; ENSGT00390000014618; -.
DR HOGENOM; CLU_726251_0_0_1; -.
DR InParanoid; G5EGF8; -.
DR OMA; CVTPGCT; -.
DR OrthoDB; 1437336at2759; -.
DR SignaLink; G5EGF8; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006580; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Metal-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..354
FT /note="Zinc finger protein tlp-1"
FT /id="PRO_0000451764"
FT ZN_FING 248..277
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 77..354
FT /note="Missing: In mh17; pointed tail tip in males, also
FT known as leptoderan (Lep) tail. Loss of asymmetry in the
FT divisions of the T cell lineage daughter cells, T.p and
FT T.ap, often resulting in loss of neural cell fates. Gross
FT morphologies of the tail tips of hermaphrodites unaffected,
FT but both males and hermaphrodites have defects in tail tip
FT cell fusion. On lin-44 mutant background, polarity of the T
FT cell division is reversed. On a lin-17 mutant background,
FT there is a loss of cell polarity in the T cell lineages,
FT resulting in the generation of only hypodermal cell fates."
FT /evidence="ECO:0000269|PubMed:11880358"
SQ SEQUENCE 354 AA; 37709 MW; EBAE2E5E53C80AEA CRC64;
MVSTHSSQYI TDFTPVPAEP GKSPLALLAK TCETIGLPEG SSKKNGASSS SSPQGKKDEK
NHILHHQHHQ QQQQSKQKSS PRSTPQSKEP TLTFPGLPKP SFPMGMPGMM QGFPFFNPMM
TAYGCFPGAF PMSQGFMGAQ RLPCPFAMMR QPCANPACVQ CPSSSSNAAK NGQMTAEMMS
QFAAHPLFSM YAGMMPGVPT SSYQALLAAS AAASTSAGPT DYSNVASTSK ASPQPKPTAQ
KSQKSAKFPC NWVDSDVPCG KVFDEENELA SHVKKMHAPS PSSSASSEQS TSTGKASRSS
TTTPHRFNPY GKPVAPAPPT MQQMGMNMAM NPLVLPFSLQ AMYSNRLMST VAHQ
