TLP2_ARATH
ID TLP2_ARATH Reviewed; 394 AA.
AC Q8GVE5; Q7Y213; Q9ZPW1;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Tubby-like F-box protein 2;
DE Short=AtTLP2;
GN Name=TULP2; OrderedLocusNames=At2g18280; ORFNames=T30D6.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=15064372; DOI=10.1104/pp.103.037820;
RA Lai C.-P., Lee C.-L., Chen P.-H., Wu S.-H., Yang C.-C., Shaw J.-F.;
RT "Molecular analyses of the Arabidopsis TUBBY-like protein gene family.";
RL Plant Physiol. 134:1586-1597(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15064372}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD15508.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY045773; AAK98801.1; -; mRNA.
DR EMBL; AC006439; AAD15508.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06748.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06749.1; -; Genomic_DNA.
DR EMBL; BT008627; AAP40448.1; -; mRNA.
DR EMBL; BT025314; ABF47130.1; -; mRNA.
DR PIR; E84562; E84562.
DR RefSeq; NP_001031369.1; NM_001036292.2.
DR RefSeq; NP_849975.1; NM_179644.2.
DR AlphaFoldDB; Q8GVE5; -.
DR SMR; Q8GVE5; -.
DR BioGRID; 1701; 5.
DR IntAct; Q8GVE5; 2.
DR STRING; 3702.AT2G18280.2; -.
DR iPTMnet; Q8GVE5; -.
DR PaxDb; Q8GVE5; -.
DR PRIDE; Q8GVE5; -.
DR EnsemblPlants; AT2G18280.1; AT2G18280.1; AT2G18280.
DR EnsemblPlants; AT2G18280.2; AT2G18280.2; AT2G18280.
DR GeneID; 816344; -.
DR Gramene; AT2G18280.1; AT2G18280.1; AT2G18280.
DR Gramene; AT2G18280.2; AT2G18280.2; AT2G18280.
DR KEGG; ath:AT2G18280; -.
DR Araport; AT2G18280; -.
DR TAIR; locus:2062121; AT2G18280.
DR eggNOG; KOG2502; Eukaryota.
DR HOGENOM; CLU_028236_3_0_1; -.
DR InParanoid; Q8GVE5; -.
DR OMA; TKSHIAP; -.
DR OrthoDB; 1445357at2759; -.
DR PhylomeDB; Q8GVE5; -.
DR PRO; PR:Q8GVE5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8GVE5; baseline and differential.
DR Genevisible; Q8GVE5; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0009536; C:plastid; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009620; P:response to fungus; IMP:TAIR.
DR Gene3D; 3.20.90.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF01167; Tub; 1.
DR PRINTS; PR01573; SUPERTUBBY.
DR SUPFAM; SSF54518; SSF54518; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..394
FT /note="Tubby-like F-box protein 2"
FT /id="PRO_0000272230"
FT DOMAIN 46..101
FT /note="F-box"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 358
FT /note="G -> V (in Ref. 4; AAP40448)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 394 AA; 43878 MW; 2BBA39F8666AEDC0 CRC64;
MSLKSILRDL KEVRDGLGGI SKRSWSKSSH IAPDQTTPPL DNIPQSPWAS LPPELLHDII
WRVEESETAW PARAAVVSCA SVCKSWRGIT MEIVRIPEQC GKLTFPISLK QPGPRDSPIQ
CFIKRNRATA TYILYYGLMP SETENDKLLL AARRIRRATC TDFIISLSAK NFSRSSSTYV
GKLRSGFLGT KFTIYDNQTA SSTAQAQPNR RLHPKQAAPK LPTNSSTVGN ITYELNVLRT
RGPRRMHCAM DSIPLSSVIA EPSVVQGIEE EVSSSPSPKG ETITTDKEIP DNSPSLRDQP
LVLKNKSPRW HEQLQCWCLN FKGRVTVASV KNFQLVAEID ASLDAPPEEH ERVILQFGKI
GKDIFTMDYR YPLSAFQAFA ICISSFDTKP ACEG
