TLP8_ARATH
ID TLP8_ARATH Reviewed; 397 AA.
AC Q9S9M8; Q8L848;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Tubby-like protein 8;
DE Short=AtTLP8;
GN Name=TULP8; OrderedLocusNames=At1g16070; ORFNames=T24D18.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=15064372; DOI=10.1104/pp.103.037820;
RA Lai C.-P., Lee C.-L., Chen P.-H., Wu S.-H., Yang C.-C., Shaw J.-F.;
RT "Molecular analyses of the Arabidopsis TUBBY-like protein gene family.";
RL Plant Physiol. 134:1586-1597(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-363.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9S9M8-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots, flowers and siliques.
CC {ECO:0000269|PubMed:15064372}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM53302.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF487269; AAQ06242.1; -; mRNA.
DR EMBL; AC010924; AAF18504.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29406.1; -; Genomic_DNA.
DR EMBL; AY120744; AAM53302.1; ALT_FRAME; mRNA.
DR EMBL; BT025624; ABF59042.1; -; mRNA.
DR PIR; E86295; E86295.
DR RefSeq; NP_173059.1; NM_101475.3. [Q9S9M8-1]
DR AlphaFoldDB; Q9S9M8; -.
DR SMR; Q9S9M8; -.
DR IntAct; Q9S9M8; 1.
DR STRING; 3702.AT1G16070.2; -.
DR PaxDb; Q9S9M8; -.
DR PRIDE; Q9S9M8; -.
DR EnsemblPlants; AT1G16070.1; AT1G16070.1; AT1G16070. [Q9S9M8-1]
DR GeneID; 838177; -.
DR Gramene; AT1G16070.1; AT1G16070.1; AT1G16070. [Q9S9M8-1]
DR KEGG; ath:AT1G16070; -.
DR Araport; AT1G16070; -.
DR eggNOG; KOG2502; Eukaryota.
DR HOGENOM; CLU_054123_2_0_1; -.
DR InParanoid; Q9S9M8; -.
DR OMA; PADWEEH; -.
DR PhylomeDB; Q9S9M8; -.
DR PRO; PR:Q9S9M8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9S9M8; baseline and differential.
DR Genevisible; Q9S9M8; AT.
DR Gene3D; 3.20.90.10; -; 1.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR Pfam; PF01167; Tub; 1.
DR PRINTS; PR01573; SUPERTUBBY.
DR SUPFAM; SSF54518; SSF54518; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..397
FT /note="Tubby-like protein 8"
FT /id="PRO_0000272236"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 346
FT /note="Q -> R (in Ref. 4; AAM53302)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 397 AA; 44488 MW; 16E28880248DC461 CRC64;
MAGSRKVNDL LEENKGNVDT ITGSLSTQKG EDKENVSPEK VSTSVETRKL DRALKSQSMK
GNSGFPTEVT NFKSFSTGGR TALKQSSLQA CMQKNSEVDK SSFGMKTWTS VDSEHSSSLK
VWEFSDSEAA PASSWSTLPN RALLCKTLPL DVGRCTCLIV KEQSPEGLSH GSVYSLYTHE
GRGRKDRKLA VAYHSRRNGK SIFRVAQNVK GLLCSSDESY VGSMTANLLG SKYYIWDKGV
RVGSVGKMVK PLLSVVIFTP TITTWTGSYR RMRTLLPKQQ PMQKNNNKQV QQASKLPLDW
LENKEKIQKL CSRIPHYNKI SKQHELDFRD RGRTGLRIQS SVKNFQLTLT ETPRQTILQM
GRVDKARYVI DFRYPFSGYQ AFCICLASID SKLCCTV
