ID   TLPB_FLAPS              Reviewed;         367 AA.
AC   Q45FN5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Protein TlpB;
GN   Name=tlpB;
OS   Flavobacterium psychrophilum.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=96345;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC   STRAIN=THC02-90;
RX   PubMed=16751514; DOI=10.1128/aem.00128-06;
RA   Alvarez B., Secades P., Prieto M., McBride M.J., Guijarro J.A.;
RT   "A mutation in Flavobacterium psychrophilum tlpB inhibits gliding motility
RT   and induces biofilm formation.";
RL   Appl. Environ. Microbiol. 72:4044-4053(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Cells show much lower levels of proteolytic
CC       activity than the wild-type, has a longer lag phase and a slightly
CC       lower growth rate and a decreased final density. It also shows
CC       attenuated virulence, deficiency in gliding motility and enhanced
CC       biofilm formation. Quantitative analysis of the thiol groups of
CC       periplasmic proteins shows that TlpB is required for the reduction of
CC       these groups. {ECO:0000269|PubMed:16751514}.
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DR   EMBL; DQ137800; AAZ53356.1; -; Genomic_DNA.
DR   RefSeq; WP_034097692.1; NZ_MTCD01000267.1.
DR   AlphaFoldDB; Q45FN5; -.
DR   SMR; Q45FN5; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   4: Predicted;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..367
FT                   /note="Protein TlpB"
FT                   /id="PRO_0000316898"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   367 AA;  41429 MW;  E65A8E3EA6FFA3CF CRC64;
     MEKVKSSYLP YTIRILISFL FIISAIAKMY PSPYFAISTF EVKQLYPLGF SEIIAPWFSR
     ILIGIELALG ILILQNNFLR KLIIPITILL LAVFVGHLSY VTFLSGGNTG NCGCFGELIP
     MTPIQAIIKN IIAIFLLVYL FFLLSKTNDK NNFYVVIGIT LATIISLFLL APIKKNTNDF
     TISPIENTLI DSTKNEIIAP ILKDSVITTV KVDSVKKAIP TKIEEVISTT EPTKHKSGYA
     KLFPKIDTGR KTLCFFVPGC DHCRKAAKEL TELKQKNANF PEILIIFMNE EVDLIPDFFK
     ETGAEYPYKI IEIIPFWNAL GTGKDTPGVK YIWNGNTYKY YNGITDNKFN PIDYQALINK
     PFSELKK