ID   TLP_BACSU               Reviewed;          83 AA.
AC   Q45060;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Small, acid-soluble spore protein Tlp;
GN   Name=tlp; Synonyms=tlpA; OrderedLocusNames=BSU18030;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969507; DOI=10.1099/13500872-142-11-3097;
RA   Rose M., Entian K.-D.;
RT   "New genes in the 170 degrees region of the Bacillus subtilis genome encode
RT   DNA gyrase subunits, a thioredoxin, a xylanase and an amino acid
RT   transporter.";
RL   Microbiology 142:3097-3101(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-12, AND SUBCELLULAR LOCATION.
RX   PubMed=9852018; DOI=10.1128/jb.180.24.6704-6712.1998;
RA   Bagyan I., Setlow B., Setlow P.;
RT   "New small, acid-soluble proteins unique to spores of Bacillus subtilis:
RT   identification of the coding genes and regulation and function of two of
RT   these genes.";
RL   J. Bacteriol. 180:6704-6712(1998).
RN   [4]
RP   INDUCTION.
RX   PubMed=10333516; DOI=10.1016/s0378-1119(99)00124-9;
RA   Cabrera-Hernandez A., Sanchez-Salas J.-L., Paidhungat M., Setlow P.;
RT   "Regulation of four genes encoding small, acid-soluble spore proteins in
RT   Bacillus subtilis.";
RL   Gene 232:1-10(1999).
CC   -!- SUBCELLULAR LOCATION: Spore core {ECO:0000269|PubMed:9852018}.
CC   -!- INDUCTION: Expressed only in the forespore compartment of sporulating
CC       cells. Disappears after 45 minutes of spore germination. Expression is
CC       sigma F and sigma G-dependent. {ECO:0000269|PubMed:10333516}.
CC   -!- SIMILARITY: Belongs to the Tlp family. {ECO:0000305}.
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DR   EMBL; Z73234; CAA97600.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13686.1; -; Genomic_DNA.
DR   PIR; C69724; C69724.
DR   RefSeq; NP_389685.1; NC_000964.3.
DR   RefSeq; WP_003231568.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; Q45060; -.
DR   SMR; Q45060; -.
DR   STRING; 224308.BSU18030; -.
DR   PaxDb; Q45060; -.
DR   PRIDE; Q45060; -.
DR   EnsemblBacteria; CAB13686; CAB13686; BSU_18030.
DR   GeneID; 938091; -.
DR   KEGG; bsu:BSU18030; -.
DR   PATRIC; fig|224308.179.peg.1965; -.
DR   eggNOG; ENOG50330RR; Bacteria.
DR   OMA; MAKPDDR; -.
DR   BioCyc; BSUB:BSU18030-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0030436; P:asexual sporulation; IEA:UniProtKB-UniRule.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   HAMAP; MF_01506; Tlp; 1.
DR   InterPro; IPR017524; SASP_thioredoxin-like.
DR   Pfam; PF19824; Tlp; 1.
DR   TIGRFAMs; TIGR03090; SASP_tlp; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Sporulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9852018"
FT   CHAIN           2..83
FT                   /note="Small, acid-soluble spore protein Tlp"
FT                   /id="PRO_0000221502"
FT   REGION          37..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   83 AA;  9722 MW;  6B7674EB7D61B8E7 CRC64;
     MTKNQNQYQQ PNPDDRSDNV EKLQDMVQNT IENIEEAEAS MEFASGEDKQ RIKEKNARRE
     QSIEAFRNEI QDESAARQNG YRS