TLR1_DROME
ID TLR1_DROME Reviewed; 504 AA.
AC P30974; Q9VGX8;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Tachykinin-like peptides receptor 86C;
DE Short=NKD;
GN Name=TkR86C; Synonyms=NKD, Takr86C; ORFNames=CG6515;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Head;
RX PubMed=1370464; DOI=10.1016/s0021-9258(18)48429-3;
RA Monnier D., Colas J.-F., Rosay P., Hen R., Borrelli E., Maroteaux L.;
RT "NKD, a developmentally regulated tachykinin receptor in Drosophila.";
RL J. Biol. Chem. 267:1298-1302(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-60.
RX PubMed=7547478; DOI=10.1016/0925-4773(95)00382-7;
RA Rosay P., Colas J.-F., Maroteaux L.;
RT "Dual organisation of the Drosophila neuropeptide receptor NKD gene
RT promoter.";
RL Mech. Dev. 51:329-339(1995).
CC -!- FUNCTION: Receptor for tachykinin-like peptides.
CC {ECO:0000269|PubMed:1370464}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1370464};
CC Multi-pass membrane protein {ECO:0000269|PubMed:1370464}.
CC -!- TISSUE SPECIFICITY: Expressed in central nervous system, as well as in
CC subsets of neurons in each segment of the developing ventral ganglia.
CC {ECO:0000269|PubMed:1370464}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development and in the adult.
CC {ECO:0000269|PubMed:1370464}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M77168; AAA28722.1; -; mRNA.
DR EMBL; AE014297; AAF54544.1; -; Genomic_DNA.
DR EMBL; S80427; AAB35334.2; -; Genomic_DNA.
DR PIR; A41783; A41783.
DR RefSeq; NP_524304.2; NM_079580.3.
DR AlphaFoldDB; P30974; -.
DR SMR; P30974; -.
DR BioGRID; 66430; 1.
DR IntAct; P30974; 1.
DR STRING; 7227.FBpp0111701; -.
DR GlyGen; P30974; 3 sites.
DR DNASU; 41286; -.
DR EnsemblMetazoa; FBtr0082315; FBpp0081791; FBgn0004841.
DR GeneID; 41286; -.
DR KEGG; dme:Dmel_CG6515; -.
DR CTD; 41286; -.
DR FlyBase; FBgn0004841; TkR86C.
DR VEuPathDB; VectorBase:FBgn0004841; -.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000155512; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P30974; -.
DR OMA; RIIFCCC; -.
DR PhylomeDB; P30974; -.
DR SignaLink; P30974; -.
DR BioGRID-ORCS; 41286; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 41286; -.
DR PRO; PR:P30974; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004841; Expressed in midline neuron (Drosophila) and 4 other tissues.
DR ExpressionAtlas; P30974; baseline and differential.
DR Genevisible; P30974; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase.
DR GO; GO:0008188; F:neuropeptide receptor activity; IDA:FlyBase.
DR GO; GO:0004995; F:tachykinin receptor activity; IDA:FlyBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISM:FlyBase.
DR GO; GO:0002121; P:inter-male aggressive behavior; IGI:FlyBase.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase.
DR GO; GO:0007217; P:tachykinin receptor signaling pathway; IDA:FlyBase.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..504
FT /note="Tachykinin-like peptides receptor 86C"
FT /id="PRO_0000070184"
FT TOPO_DOM 1..84
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..108
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..143
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..179
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..224
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..275
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..330
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..343
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..367
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 368..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 393..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 187
FT /note="H -> D (in Ref. 1; AAA28722)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="H -> Q (in Ref. 1; AAA28722)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="Y -> T (in Ref. 1; AAA28722)"
FT /evidence="ECO:0000305"
FT CONFLICT 281..282
FT /note="LW -> PG (in Ref. 1; AAA28722)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 504 AA; 58020 MW; 723C9622F3B663B9 CRC64;
MSEIVDTELL VNCTILAVRR FELNSIVNTT LLGSLNRTEV VSLLSSIIDN RDNLESINEA
KDFLTECLFP SPTRPYELPW EQKTIWAIIF GLMMFVAIAG NGIVLWIVTG HRSMRTVTNY
FLLNLSIADL LMSSLNCVFN FIFMLNSDWP FGSIYCTINN FVANVTVSTS VFTLVAISFD
RYIAIVHPLK RRTSRRKVRI ILVLIWALSC VLSAPCLLYS SIMTKHYYNG KSRTVCFMMW
PDGRYPTSMA DYAYNLIILV LTYGIPMIVM LICYSLMGRV LWGSRSIGEN TDRQMESMKS
KRKVVRMFIA IVSIFAICWL PYHLFFIYAY HNNQVASTKY VQHMYLGFYW LAMSNAMVNP
LIYYWMNKRF RMYFQRIICC CCVGLTRHRF DSPKSRLTNK NSSNRHTRAE TKSQWKRSTM
ETQIQQAPVT SSCREQRSAQ QQQPPGSGTN RAAVECIMER PADGSSSPLC LSINNSIGER
QRVKIKYISC DEDNNPVELS PKQM
